Study Report
Reference
| Citation | Dillon, 2010 PubMed |
| Full Info | Dillon, D.G., Bogdan, R., Fagerness, J., Holmes, A.J., Perlis, R.H. and Pizzagalli, D.A. (2010) Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans. Hum Brain Mapp, 31, 210-221.
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Study
| Hypothesis or Background |
The TREK1 gene has been linked to a depression-resistant phenotype in rodents and antidepressant response in humans, but the neural mechanisms underlying these links are unclear. Because TREK1 is expressed in reward-related basal ganglia regions, it has been hypothesized that TREK1 genetic variation may be associated with anhedonic symptoms of depression.
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| Sample Information | healthy individuals (n = 31) |
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| Method Detail | To investigate whether TREK1 genetic variation influences reward processing, we genotyped healthy individuals (n = 31) who completed a monetary incentive delay task during functional magnetic resonance imaging (fMRI). |
| Method Keywords | functional magnetic resonance imaging (fMRI); genotyping |
| Result | Three genotypes previously linked to positive antidepressant response were associated with potentiated basal ganglia activity to gains, but did not influence responses to penalties or no change feedback. TREK1 genetic variations did not affect basal ganglia volume, and fMRI group differences were confirmed when accounting for self-report measures of anhedonia. In addition, the total number of protective TREK1 alleles was associated with stronger responses to gains in several other reward-related regions, including the dorsal anterior cingulate cortex, orbitofrontal cortex, and mesial prefrontal cortex. In control analyses, associations between basal ganglia responses to gains and functional polymorphisms in the dopamine transporter (DAT1) and catechol-O-methyltransferase (COMT) genes were also explored. Results revealed that TREK1 and DAT/COMT genotypes were independently related to basal ganglia responses to gains. |
| Conclusions | These findings indicate that TREK1 genotypes are associated with individual differences in reward-related brain activity. Future studies in depressed samples should evaluate whether variation in neural responses to rewards may contribute to the association between TREK1 and antidepressant response in humans. |
Relationships reported by
Dillon, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
Basal ganglia (basal ganglia)
|
brain morphology and function |
COMT (catechol-O-methyltransferase (COMT)) |
gene |
|
Results revealed that TREK1 and DAT/COMT genotypes were independently related to basal ganglia responses to gains. |
Positive
|
|
Orbitofrontal cortex (orbitofrontal cortex)
|
brain morphology and function |
KCNK2 (TREK1) |
gene |
|
the total number of protective TREK1 alleles was associated with stronger responses to gains in several other reward-related regions, including the orbitofrontal cortex. |
Positive
|
|
medial prefrontal cortex (MPFC) (mesial prefrontal cortex)
|
brain morphology and function |
KCNK2 (TREK1) |
gene |
|
the total number of protective TREK1 alleles was associated with stronger responses to gains in several other reward-related regions, including the mesial prefrontal cortex. |
Positive
|
|
dorsal anterior cingulate cortex (dorsal anterior cingulate cortex)
|
brain morphology and function |
KCNK2 (TREK1) |
gene |
|
the total number of protective TREK1 alleles was associated with stronger responses to gains in several other reward-related regions, including the dorsal anterior cingulate cortex. |
Positive
|
|
Basal ganglia (basal ganglia)
|
brain morphology and function |
SLC6A3 (dopamine transporter (DAT1)) |
gene |
|
Results revealed that TREK1 and DAT/COMT genotypes were independently related to basal ganglia responses to gains. |
Positive
|
|
Anhedonia (anhedonia)
|
symptoms |
KCNK2 (TREK1) |
gene |
|
TREK1 genetic variations did not affect basal ganglia volume, and fMRI group differences were confirmed when accounting for self-report measures of anhedonia. |
Positive
|
|
Reward system (brain reward system)
|
brain morphology and function |
KCNK2 (TREK1) |
gene |
|
Results revealed that TREK1 and DAT/COMT genotypes were independently related to basal ganglia responses to gains. These findings indicate that TREK1 genotypes are associated with individual differences in reward-related brain activity. |
Positive
|
