Brain Morphology and Function Report

Name	subgenual anterior cingulate
Brain Morphology	Please reference to the description for Anterior cingulate cortex
No. of Studies (Positive/Negative)	8(8/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
subgenual anterior cingulate cortex	Neumeister, 2006	patients and normal controls		A direct effect of 5-HTTLPR on the regulation of regional ce...... A direct effect of 5-HTTLPR on the regulation of regional cerebral metabolic rates for glucose was identified in patients with rMDD for the amygdala, hippocampus, and subgenual anterior cingulate cortex. More...
subgenual ACC-based neural network	Cullen, 2009	patients and normal controls		Seed-based connectivity analysis revealed that adolescents w...... Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). More...
subgenual anterior cingulate cortex (ACC)	Cullen, 2009	patients and normal controls		Seed-based connectivity analysis revealed that adolescents w...... Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). More...
subgenual anterior cingulate	Cooney, 2010	patients and normal controls		Depressed participants exhibited increased activation in the...... Depressed participants exhibited increased activation in the orbitofrontal cortex, subgenual anterior cingulate, and dorsolateral prefrontal cortex as compared with healthy controls during rumination versus concrete distraction. More...
subgenual anterior cingulate cortex (ACC)	Holsen, 2011	patients and normal controls		fMRI results showed greater BOLD signal intensity changes in...... fMRI results showed greater BOLD signal intensity changes in controls versus MDD in hypothalamus, amygdala, hippocampus, OFC, ACC, and subgenual ACC, findings unrelated to medication status. More...
subgenual anterior cingulate cortex (sgACC)	Tripp, 2011	patients and normal controls		SgACC SST was reduced in MDD patients. SgACC SST was reduced in MDD patients.
subgenual anterior cingulate cortex (sACC)	Niida, 2011	patients and normal controls		sACC volume reduction was noted in 66 of the 71 patients rec...... sACC volume reduction was noted in 66 of the 71 patients receiving treatment of MDD, with sensitivity of 93%, specificity of 85%, and accuracy of 90%.That patients receiving treatment of MDD often showed reduction in sACC volume suggests the usefulness of this parameter as an objective auxiliary means of diagnosis for MDD. More...
subgenual anterior cingulate cortex (sACC)	Steiner, 2011	patients and normal controls	P-value = 0.003	Depressed patients had a significantly increased density of ...... Depressed patients had a significantly increased density of QUIN-positive cells in the sACC (P = 0.003) compared to controls. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
subgenual anterior cingulate cortex		SLC6A4(5-HTTLPR)	gene	Neumeister, 2006	patients and normal controls		A direct effect of 5-HTTLPR on the regulation of regional ce...... A direct effect of 5-HTTLPR on the regulation of regional cerebral metabolic rates for glucose was identified in patients with rMDD for the amygdala, hippocampus, and subgenual anterior cingulate cortex. More...
subgenual anterior cingulate		Interleukin-18(IL-18)	protein	Prossin, 2011	patients and normal controls		In MDDs, IL-18 was positively correlated with baseline regio...... In MDDs, IL-18 was positively correlated with baseline regional mu-OR BP(ND) and with sadness-induced mu-opioid system activation in the subgenual anterior cingulate, ventral basal ganglia, and amygdala. More...
subgenual anterior cingulate cortex (ACC)		Estradiol(estradiol)	molecule	Holsen, 2011	patients and normal controls		Hypoactivations in hypothalamus, subgenual ACC, amygdala and...... Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. More...
subgenual anterior cingulate cortex (ACC)		Progesterone(progesterone)	molecule	Holsen, 2011	patients and normal controls		Hypoactivations in hypothalamus, subgenual ACC, amygdala and...... Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. More...
subgenual ACC-based neural network		Insular cortex(insular cortex)	brain morphology and function	Cullen, 2009	patients and normal controls		Seed-based connectivity analysis revealed that adolescents w...... Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). More...
subgenual ACC-based neural network		left inferior frontal cortex(left inferior frontal cortex)	brain morphology and function	Cullen, 2009	patients and normal controls		Seed-based connectivity analysis revealed that adolescents w...... Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). More...
subgenual ACC-based neural network		right medial frontal cortex(right medial frontal cortex)	brain morphology and function	Cullen, 2009	patients and normal controls		Seed-based connectivity analysis revealed that adolescents w...... Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). More...
subgenual anterior cingulate cortex (ACC)		subgenual anterior cingulate(subgenual ACC-based neural network)	brain morphology and function	Cullen, 2009	patients and normal controls		Seed-based connectivity analysis revealed that adolescents w...... Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). More...
subgenual ACC-based neural network		superior frontal cortex(superior frontal cortex)	brain morphology and function	Cullen, 2009	patients and normal controls		Seed-based connectivity analysis revealed that adolescents w...... Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). More...
subgenual ACC-based neural network		Superior temporal gyrus(superior temporal gyrus)	brain morphology and function	Cullen, 2009	patients and normal controls		Seed-based connectivity analysis revealed that adolescents w...... Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). More...

---

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web