Pathway Report

Basic Information

Name	protein kinase B signaling cascade
GO Link	ID: GO:0043491 Name: protein kinase B signaling cascade Type: biological process
No. of Studies (Positive/Negative)	2 (2/0)

Positive relationship between protein kinase B signaling cascade and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Akt	Karege, 2007	patients and normal controls	F(3,36)=5.372; P-value= 0.003	The enzyme activity of Akt decreased significantly [analysis...... The enzyme activity of Akt decreased significantly [analysis of variance (ANOVA): F(3,36)=5.372; p= .003], whereas GSK-3beta activity increased significantly [ANOVA: F(3,36)=8.567; p= .002] in depressed suicide victims and non-suicide subjects but not in non-depressed suicide victims. More...

Positive relationships between protein kinase B signaling cascade and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Akt		Disrupted in schizophrenia 1 protein(DISC1)	protein	Hashimoto, 2006	patients and normal controls; cell model		In primary neuronal culture, knockdown of endogenous DISC1 p...... In primary neuronal culture, knockdown of endogenous DISC1 protein by small interfering RNA resulted in the suppression of phosphorylation of ERK and Akt, whose signaling pathways are implicated in MDD. More...

Positive relationship network of protein kinase B signaling cascade in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between protein kinase B signaling cascade and MDD (count: 0)

Negative relationships between protein kinase B signaling cascade and other components at different levels (count: 0)

Pathway protein kinase B signaling cascade related genes in MK4MDD (count: 5)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
P2RY12	purinergic receptor P2Y, G-protein coupled, 12	Literature-origin	1(1/0)
GAS6	growth arrest-specific 6	Literature-origin	1(1/0)
TNF	tumor necrosis factor	Literature-origin; SNP mapped; Protein mapped	5(5/0)
IL1B	interleukin 1, beta	Literature-origin; SNP mapped; Protein mapped	3(2/1)
CCL2	chemokine (C-C motif) ligand 2	Literature-origin; SNP mapped; Protein mapped	2(1/1)