Gene Report

Basic Information

Approved Symbol	GAS6
Approved Name	growth arrest-specific 6
Previous Symbol	AXLLG
Symbol Alias	AXSF, FLJ34709, DKFZp666G247
Name Alias	AXL stimulatory factor
Location	13q34
Position	chr13:114523522-114567046 (-)
External Links	Entrez Gene: 2621 Ensembl: ENSG00000183087 UCSC: uc001vud.3 HGNC ID: 4168
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between GAS6 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Growth arrest-specific 6	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between GAS6 and other components at different levels (count: 0)

Positive relationship network of GAS6 in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GAS6 and MDD (count: 0)

Negative relationships between GAS6 and other components at different levels (count: 0)

GAS6 related SNPs in MK4MDD (count: 0)

GAS6 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Growth arrest-specific protein 6	Q14393	0(0/0)	Gene mapped

GAS6 related GO terms (count: 90)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0043491	protein kinase B signaling cascade	biological process	IDA[16723520]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0002576	platelet degranulation	biological process	TAS
GO:0050766	positive regulation of phagocytosis	biological process	IDA[18395422]
GO:0035457	cellular response to interferon-alpha	biological process	IDA[19657094]
GO:0048146	positive regulation of fibroblast proliferation	biological process	IDA[15184064]
GO:0032720	negative regulation of tumor necrosis factor production	biological process	IDA
GO:0007155	cell adhesion	biological process	TAS[16564713]
GO:0050900	leukocyte migration	biological process	TAS
GO:0032148	activation of protein kinase B activity	biological process	ISS
GO:0070168	negative regulation of biomineral tissue development	biological process	IDA
GO:0070527	platelet aggregation	biological process	TAS[16564713]
GO:0006468	protein phosphorylation	biological process	IDA[16359517]
GO:0043066	negative regulation of apoptotic process	biological process	IDA[19922767]
GO:0072661	protein targeting to plasma membrane	biological process	IDA[16359517]
GO:0005615	extracellular space	cellular component	IDA[8336730]
GO:0007167	enzyme linked receptor protein signaling pathway	biological process	IEA
GO:0032689	negative regulation of interferon-gamma production	biological process	IDA[18840707]
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IDA[18680538]
GO:0007596	blood coagulation	biological process	TAS
GO:0097028	dendritic cell differentiation	biological process	IEP[19657094]
GO:0051897	positive regulation of protein kinase B signaling cascade	biological process	IDA[16723520]
GO:2000510	positive regulation of dendritic cell chemotaxis	biological process	IDA[19657094]
GO:0044267	cellular protein metabolic process	biological process	TAS
GO:0005576	extracellular region	cellular component	TAS
GO:0050711	negative regulation of interleukin-1 secretion	biological process	IDA
GO:0061098	positive regulation of protein tyrosine kinase activity	biological process	IDA
GO:0005515	protein binding	molecular function	IPI[18760998]
GO:0046718	viral entry into host cell	biological process	IDA
GO:0030296	protein tyrosine kinase activator activity	molecular function	IDA
GO:0010934	macrophage cytokine production	biological process	IEA
GO:0003104	positive regulation of glomerular filtration	biological process	ISS
GO:0009267	cellular response to starvation	biological process	IEA
GO:0040008	regulation of growth	biological process	IEA
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	IDA[16723520]
GO:0045860	positive regulation of protein kinase activity	biological process	IDA[7854420]
GO:0035690	cellular response to drug	biological process	IDA[16359517]
GO:0035754	B cell chemotaxis	biological process	IDA[19922767]
GO:0017187	peptidyl-glutamic acid carboxylation	biological process	TAS
GO:0097241	hematopoietic stem cell migration to bone marrow	biological process	IDA[19922767]
GO:0060090	binding, bridging	molecular function	IDA
GO:0006508	proteolysis	biological process	TAS
GO:0006909	phagocytosis	biological process	IDA
GO:0070588	calcium ion transmembrane transport	biological process	IDA[18395422]
GO:0071363	cellular response to growth factor stimulus	biological process	IEA
GO:0008283	cell proliferation	biological process	TAS[16564713]
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	biological process	IDA[19657094]
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IDA[15184064]
GO:0043687	post-translational protein modification	biological process	TAS
GO:0001961	positive regulation of cytokine-mediated signaling pathway	biological process	IMP[18840707]
GO:0007050	cell cycle arrest	biological process	TAS[16564713]
GO:0043277	apoptotic cell clearance	biological process	IDA
GO:0046813	virion attachment, binding of host cell surface receptor	biological process	IDA
GO:0005102	receptor binding	molecular function	IDA[16359517]; IPI[7854420]
GO:0005245	voltage-gated calcium channel activity	molecular function	IDA[18395422]
GO:0005788	endoplasmic reticulum lumen	cellular component	TAS
GO:0019079	viral genome replication	biological process	IDA
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	molecular function	IDA[16723520]
GO:0030971	receptor tyrosine kinase binding	molecular function	IPI[7634325]
GO:0085029	extracellular matrix assembly	biological process	ISS
GO:1900142	negative regulation of oligodendrocyte apoptotic process	biological process	IDA[16723520]
GO:0019064	viral entry into host cell via membrane fusion with the plasma membrane	biological process	IDA
GO:0001764	neuron migration	biological process	IEA
GO:2000669	negative regulation of dendritic cell apoptotic process	biological process	IDA[19657094]
GO:0005796	Golgi lumen	cellular component	TAS
GO:0032825	positive regulation of natural killer cell differentiation	biological process	IDA[18840707]
GO:0046827	positive regulation of protein export from nucleus	biological process	IDA[18680538]
GO:0005737	cytoplasm	cellular component	IDA[18395422]
GO:0071307	cellular response to vitamin K	biological process	IDA[16359517]
GO:0031100	organ regeneration	biological process	IEA
GO:0032008	positive regulation of TOR signaling cascade	biological process	ISS
GO:1900165	negative regulation of interleukin-6 secretion	biological process	IDA
GO:0031093	platelet alpha granule lumen	cellular component	TAS
GO:0010628	positive regulation of gene expression	biological process	IDA[19657094]
GO:0007165	signal transduction	biological process	IDA[7854420]; TAS[16564713]
GO:0005509	calcium ion binding	molecular function	IEA
GO:0048018	receptor agonist activity	molecular function	IDA[15184064]
GO:0001934	positive regulation of protein phosphorylation	biological process	IDA[16723520]; ISS
GO:0071333	cellular response to glucose stimulus	biological process	ISS
GO:0032715	negative regulation of interleukin-6 production	biological process	IDA[19657094]
GO:0016477	cell migration	biological process	TAS[16564713]
GO:0031589	cell-substrate adhesion	biological process	IEA
GO:0018105	peptidyl-serine phosphorylation	biological process	IDA
GO:2000533	negative regulation of renal albumin absorption	biological process	ISS
GO:0033159	negative regulation of protein import into nucleus, translocation	biological process	IDA
GO:2000352	negative regulation of endothelial cell apoptotic process	biological process	IDA[18760998]
GO:0033138	positive regulation of peptidyl-serine phosphorylation	biological process	IDA[16723520]
GO:0001786	phosphatidylserine binding	molecular function	IDA
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	biological process	IDA[18680538]
GO:0030168	platelet activation	biological process	TAS
GO:2000270	negative regulation of fibroblast apoptotic process	biological process	IDA[16359517]

GAS6 related KEGG pathways (count: 0)

GAS6 related BioCarta pathways (count: 0)

GAS6 related Reactome pathways (count: 9)

ID	Name	Description
Gene mapped Reactome pathways
REACT_6900	signaling in_immune_system	Humans are exposed to millions of potential pathogens daily,...... Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system. More...
REACT_798	platelet activation	Platelet activation begins with the initial binding of adhes...... Platelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists. Intracellular signaling reactions will then enhance the adhesive and procoagulant properties of tethered platelets or of platelets circulating in the proximity. From the subendothelial adhesive substrates, collagen and possibly vWF are the main inducers of platelet activation. GP VI is the most potent collagen receptor initiating signal generation, an ability derived from its interaction with the FcRI gamma chain. This results in the phosphorylation of the gamma-chain by the non-receptor tyrosine kinases of the Src family. The phosphotyrosine motif is recognized by the SH2 domains of Syk, a tyrosine kinase. This association activates the Syk enzyme, leading to activation. Four PARs are identified, of which PARs 1 ,3 and 4 are substrates for thrombin. PAR 1 is the predominant thrombin receptor, PAR 3 is minimally expressed and PAR 4 is less responsive to thrombin. Platelets do not store PAR1, due to limited protein synthesis, they are capable of responding to thrombin only once. Platelet activation further results in the scramblase-mediated transport of negatively-charged phospholipids to the platelet surface. These phospholipids provide a catalytic surface (with the charge provided by phosphatidylserine and phosphatidylethanolamine) for the tenase complex (formed by the activated forms of the blood coagulation factors factor VIII and factor I). More...
REACT_318	platelet degranulation	Platelets function as exocytotic cells, secreting a plethora...... Platelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules, dense granules and lysosomes. On activation platelets release a variety of proteins, largely from storage granules but also as the result of apparent cell lysis. These act in an autocrine or paracrine fashion to modulate cell signaling. Alpha granules contain mainly polypeptides such as fibrinogen, von Willebrand factor, growth factors and protease inhibitors that that supplement thrombin generation at the site of injury. Dense granules contain small molecules, particularly adenosine diphosphate (ADP), adenosine triphosphate (ATP), serotonin and calcium, all recruit platelets to the site of injury. More...
REACT_17015	metabolism of_proteins	Protein metabolism comprises the pathways of translation, po...... Protein metabolism comprises the pathways of translation, post-translational modification and protein folding. More...
REACT_1132	gamma carboxylation_transport_and_amino_terminal_cleavage_of_proteins	A number of proteins, including eight required for normal bl...... A number of proteins, including eight required for normal blood clot formation and its regulation (Prothrombin (factor II), factor VII, factor IX, factor X, protein C, protein S, protein Z, and Gas6) share a sequence motif rich in glutamate residues near their amino termini. Carboxylation of the glutamate residues within this motif followed by removal of an aminoterminal propeptide is required for each of these proteins to function. These modifications occur as the proteins move through the endoplasmic reticulum and Golgi apparatus. More...
REACT_12051	cell surface_interactions_at_the_vascular_wall	Leukocyte extravasation is a rigorously controlled process t...... Leukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are required for leukocytes to withstand local flow at the vessel wall is a multistep process mediated by different adhesion molecules. Platelets adhered to injured vessel walls form strong adhesive substrates for leukocytes. For instance, the initial tethering and rolling of leukocytes over the site of injury are mediated by reversible binding of selectins to their cognate cell-surface glycoconjugates. Endothelial cells are tightly connected through various proteins, which regulate the organization of the junctional complex and bind to cytoskeletal proteins or cytoplasmic interaction partners that allow the transfer of intracellular signals. An important role for these junctional proteins in governing the transendothelial migration of leukocytes under normal or inflammatory conditions has been established. This pathway describes some of the key interactions that assist in the process of platelet and leukocyte interaction with the endothelium, in response to injury. More...
REACT_604	hemostasis	Two principal mechanisms limit blood loss after vascular inj...... Two principal mechanisms limit blood loss after vascular injury. Initially, platelets are activated, adhere to the site of the injury, and aggregate into a plug that limits blood loss. Proteins and small molecules released from activated platelets stimulate the plug formation process, and fibrinogen from the plasma forms bridges between activated platelets. These events allow the initiation of the clotting cascade, the second mechanism to limit blood loss. Negatively charged phospholipids exposed on cell surfaces at the site of injury and on activated platelets interact with tissue factor, setting off a cascade of reactions leading to generation of fibrin and the formation of an insoluble fibrin clot that strengthens the platelet plug. More...
REACT_20	formation of_platelet_plug	Hemostasis is a physiological response that culminates in th...... Hemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Acute vessel injury results in its constriction to reduce the loss of blood. Under normal conditions vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma vasoconstrictor mechanisms predominate and the endothelium becomes prothrombotic, procoagulatory and proinflammatory in nature. This is achieved by a reduction of endothelial dilating agents: adenosine, NO and prostacyclin; and the direct action of ADP, serotonin and thromboxane on vascular smooth muscle cells to elicit their contraction. The chief trigger for the change in endothelial function that leads to the formation of haemostatic thrombus is the loss of the endothelial cell barrier between blood and ECM components. Circulating platelets identify and discriminate areas of endothelial lesions; here, they adhere to the exposed sub endothelium. Their interaction with the various thrombogenic substrates and locally generated or released agonists results in platelet activation. This process is described as possessing two stages, firstly, adhesion - the initial tethering to a surface, and secondly aggregation - the platelet-platelet cohesion. More...
REACT_1069	post translational_protein_modification	After translation, many newly formed proteins undergo furthe...... After translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the body. These modifications include the internal peptide bond cleavages that activate proenzymes, the attachment of oligosaccharide moieties to membrane-bound and secreted proteins, the attachment of lipid or glycolipid moieties that serve to anchor proteins to cellular membranes, and the vitamin K-dependent attachment of carboxyl groups to glutamate residues. More...

GAS6 related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GAS6	AXL	No	in vitro	8621659 , 16362042
GAS6	TYRO3	No	in vitro	8621659 , 8939948
GAS6	MERTK	No	in vitro	8939948

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways