MK4MDD

Pathway Report

Basic Information
Name protein kinase B signaling cascade
GO Link ID: GO:0043491
Name: protein kinase B signaling
Type: biological process
No. of Studies (Positive/Negative) 2 (2/0) Help

Positive relationship between protein kinase B signaling cascade and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
Akt Karege, 2007 patients and normal controls F(3,36)=5.372; P-value= 0.003 The enzyme activity of Akt decreased significantly [analysis...... The enzyme activity of Akt decreased significantly [analysis of variance (ANOVA): F(3,36)=5.372; p= .003], whereas GSK-3beta activity increased significantly [ANOVA: F(3,36)=8.567; p= .002] in depressed suicide victims and non-suicide subjects but not in non-depressed suicide victims. More...

Positive relationships between protein kinase B signaling cascade and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of protein kinase B signaling cascade in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between protein kinase B signaling cascade and MDD (count: 0)
Negative relationships between protein kinase B signaling cascade and other components at different levels (count: 0) Help
Pathway protein kinase B signaling cascade related genes in MK4MDD (count: 8)