Pathway Report

Basic Information

Name	oxidoreductase activity
GO Link	ID: GO:0016491 Name: oxidoreductase activity Type: molecular function
Description	Genes annotated by the GO term GO:0016491. Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No. of Studies (Positive/Negative)	1 (1/0)

Positive relationship between oxidoreductase activity and MDD (count: 0)

Positive relationships between oxidoreductase activity and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Oxidoreductase activity		Stress(stress)	environment	Tordera RM, 2011	animal model		After CMS, Specifically, a dowregulation in genes that promo...... After CMS, Specifically, a dowregulation in genes that promote cell proliferation (Anapc7), cell growth (CsnK1g1), cell survival (Hdac3), and inhibition of apoptosis (Dido1) was observed. Genes linked to cytoskeleton (Hspg2, Invs), psychiatric disorders (Grin1, MapK12) or an antioxidant enzyme (Gpx2) were also downregulated. Moreover, genes that inhibit the MAPK pathways (Dusp14), stimulate oxidative metabolism (Eif4a2) and enhance glutamate transmission (Rab8b) were upregulated. More...

Positive relationship network of oxidoreductase activity in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between oxidoreductase activity and MDD (count: 0)

Negative relationships between oxidoreductase activity and other components at different levels (count: 0)

Pathway oxidoreductase activity related genes in MK4MDD (count: 3)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
FADS1	fatty acid desaturase 1	Literature-origin	2(2/0)
HSD17B6	hydroxysteroid (17-beta) dehydrogenase 6	Literature-origin	1(1/0)
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	Literature-origin; SNP mapped	1(1/0)