Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal (GI) tract, platelets, and in the central nervous system (CNS) of animals including humans. Serotonin is mainly metabolized to 5-HIAA, chiefly by the liver. Metabolism involves first oxidation by monoamine oxidase ( MAO ) to the corresponding aldehyde. This is followed by oxidation by aldehyde dehydrogenase to 5-HIAA, the indole acetic acid derivative. Serotonin is a neurotransmitter, and is found in all bilateral animals, where it mediates gut movements and the animal's perception of resource availability. The neurons of the raphe nuclei are the principal source of 5-HT release in the brain.
Picture
From Wiki.
No. of Studies (Positive/Negative)
11 (11/0)
Positive relationship between Serotonergic system and MDD (count: 4)
decrease (33%) in serum cortisol levels was observed in depressed patients
The blunted cortisol responsiveness to fenfluramine (FNF) ad......
The blunted cortisol responsiveness to fenfluramine (FNF) administration in depressed patients may reflect functional hypoactivity of central serotonergic system at least during the acute phase of major depression.More...
Within Brodmann's area 32, a glucose metabolism deficit in t......
Within Brodmann's area 32, a glucose metabolism deficit in the depressed subjects on placebo day was observed by voxel-level analysis, but no volumetric deficit was found in the subgenual regions examined.More...
The lack of difference in the response to fenfluramine admin......
The lack of difference in the response to fenfluramine administration between unipolar and bipolar depressed patients may indicate that overall serotonergic function in unipolar and bipolar depressed patients is similarly impaired.More...
Unlike healthy male subjects who have significant increases ......
Unlike healthy male subjects who have significant increases in rCMRglu in prefrontal and parietal cortical regions after receiving fenfluramine, depressed male subjects have no significant increases in rCMRglu. Blunted increases in rCMRglu in response to fenfluramine in prefrontal and parietal cortex are consistent with our previous pilot study and the indoleamine hypothesis of depression. More...
Positive relationships between Serotonergic system and other components at different levels (count: 17)
Genetic/epigenetic locus
Protein and other molecule
Cell and molecular pathway
Neural system
Cognition and behavior
Symptoms and signs
Environment
Positive relationship network of Serotonergic system in MK4MDD
Network loading ...
Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus
Protein and Other Molecule
Cell and Molecular Pathway
Neural System
Cognition and Behavior
Symptoms and Signs
Environment
MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node.
Right-click will show also the menus to link to the report page of the node and remove the node and related edges.
Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web
Negative relationships between Serotonergic system and MDD (count: 0)
Negative relationships between Serotonergic system and other components at different levels (count: 0)
Serotonergic system involved components (count: 13)
Basic Information
From Wiki.
Positive relationships between Serotonergic system and other components at different levels (count: 17)
