Brain Morphology and Function Report

Name	Occipital Lobe
Brain Morphology	The two occipital lobes are the smallest of four paired lobes in the human cerebral cortex. Located in the rearmost portion of the skull, the occipital lobes are part of the forebrain. The cortical lobes are not defined by any internal structural features, but rather by the bones of the skull that overlie them. Thus, the occipital lobe is defined as the part of the cerebral cortex that lies underneath the occipital bone. The occipital lobe is the visual processing center of the mammalian brain containing most of the anatomical region of the visual cortex.
Brain Function	Occipital Lobe- associated with visual processing
Picture	Source
No. of Studies (Positive/Negative)	11(11/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
occipital cortex	Costafreda, 2009	patients and normal controls		Of the patients who subsequently achieved clinical remission...... Of the patients who subsequently achieved clinical remission with antidepressant medication, clinical remission was predicted by greater grey matter density in the right occipital cortex (BA 19). Decreased grey matter density in the occipital (BA 19) cortex showed the highest contribution to the diagnosis of depression. More...
occipital cortex	Drevets, 1999	patients and normal controls		The mean 5HT1A receptor BP was reduced in the occipital cort...... The mean 5HT1A receptor BP was reduced in the occipital cortex in the depressives relative to the controls. More...
occipital cortex	Bonte, 2001	patients and normal controls		Two groups of patients were identified: 8 with significant p...... Two groups of patients were identified: 8 with significant posterior flow deficits in the occipital cortex (Brodmann's areas 18 and 19), usually symmetric, and best visualized on paramedian sagittal sections, and 13 without obvious occipital perfusion deficits but with anterior rCBF deficits in a pattern often described in the literature, attaining statistical significance in the right frontal region. More...
occipital cortices	Messa, 2003	patients and normal controls	P-value = 0.003 ANOVA; P-value = 0.001 ANCOVA	A significant reduction in binding index (BI) of [(18)F]FESP...... A significant reduction in binding index (BI) of [(18)F]FESP ( P=0.003 ANOVA, P=0.001 ANCOVA) was found in DN(drug-naive) patients in the frontal, occipital, temporal and cingulate cortices More...
occipital cortex	Sanacora, 2004	patients and normal controls	P-value = 0.01	Depressed subjects had significantly lower occipital cortex ...... Depressed subjects had significantly lower occipital cortex GABA concentrations compared with healthy controls (P =.01). More...
occipital cortex	Nofzinger, 2005	patients and normal controls		Depressed patients showed larger decreases than healthy subj...... Depressed patients showed larger decreases than healthy subjects in relative metabolism in the occipital cortex. More...
occipital lobe	Abe, 2010	patients and normal controls		Local areas showing significant gray matter volume reduction...... Local areas showing significant gray matter volume reduction in depressive patients compared with controls were observed in the occipital lobe More...
occipital cortex	Maciag, 2010	patients and normal controls		The density of CB-IR neurons in layer II of the occipital co...... The density of CB-IR neurons in layer II of the occipital cortex was significantly decreased in major depressive disorder subjects compared with the control group. More...
occipital cortices	Townsend, 2010	patients and normal controls		In a between-group comparison, patients showed significantly...... In a between-group comparison, patients showed significantly reduced activation in the insula, temporal and occipital cortices. More...
occipital lobe	Peng, 2011	patients and normal controls		ReHo (regional homogeneity) in the left thalamus, left tempo...... ReHo (regional homogeneity) in the left thalamus, left temporal lobe, left cerebellar posterior lobe, and the bilateral occipital lobe was found to be significantly decreased in depression compared to healthy controls in resting state of depression. More...
occipital regions	Zhang, 2011	patients and normal controls		The MDD patients exhibited reduced nodal centralities in the...... The MDD patients exhibited reduced nodal centralities in the occipital regions. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
occipital cortex		5-hydroxytryptamine receptor 1A(5HT1A receptor (serotonin-1A receptor))	protein	Drevets, 1999	patients and normal controls		The mean 5HT1A receptor BP was reduced in the occipital cort...... The mean 5HT1A receptor BP was reduced in the occipital cortex in the depressives relative to the controls. More...

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Note:
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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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