Molecule Report

Name	Nitric oxide
Description	A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
MeSH ID	D009569
No. of Studies (Positive/Negative)	6(6/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NO	Selley, 2004	patients and normal controls	P-value<0.0001	There was a significant decrease in the plasma concentration...... There was a significant decrease in the plasma concentration of NO (P<0.0001). More...
nitric oxide (NO)	Chrapko, 2004	patients and normal controls		The levels of both plasma Nox(NO metabolite) and platelet eN...... The levels of both plasma Nox(NO metabolite) and platelet eNOS(endothelial NO synthase) activity were significantly lower in subjects with major depression compared with healthy control subjects. More...
Nox	Chrapko, 2004	patients and normal controls		The levels of both plasma NOx and platelet eNOS activity wer...... The levels of both plasma NOx and platelet eNOS activity were significantly lower in subjects with major depression compared with healthy control subjects. More...
nitric oxide	Lee, 2006	patients and normal controls	t=-3.090, d.f.=84, P-value=0.003	Among the patients with a diagnosis of major depression, sui...... Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma nitric oxide metabolites NO(x) levels than non-suicidal depressive patients (t=-3.090, d.f.=84, p=0.003). More...
nitric oxide (NO)	Arslan, 2008	patients and normal controls	P-value < 0.05	MD (major depression) group had significantly lower plasma N...... MD (major depression) group had significantly lower plasma NO levels compared to healthy women (12.7 +/- 1.4 vs. 21.82 +/- 3.5 microM, respectively, p < 0.05). More...
Nox(nitric oxide)	Ikenouchi-Sugita, 2009	patients and normal controls	P-value<0.01	The baseline plasma NOx levels were significantly lower in t...... The baseline plasma NOx levels were significantly lower in the whole depressed group than in the control group (p<0.01). More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
NO		N,N-dimethylarginine(ADMA)	molecule	Selley, 2004	patients and normal controls	r=-0.595, P-value<0.0001	A significant negative correlation was detected between the ...... A significant negative correlation was detected between the plasma concentrations of ADMA and NO (r=-0.595, P<0.0001). More...
nitric oxide		Suicide(suicide)	symptoms	Lee, 2006	patients and normal controls	t=-3.090, d.f.=84, P-value=0.003	Among the patients with a diagnosis of major depression, sui...... Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma nitric oxide metabolites NO(x) levels than non-suicidal depressive patients (t=-3.090, d.f.=84, p=0.003). More...
nitric oxide (NO)		Blood pressure (BP)(systolic blood pressures)	signs	Arslan, 2008	patients and normal controls	r = -0.50; P-value < 0.01	There was a significant negative correlation between plasma ...... There was a significant negative correlation between plasma NO levels and SBP(systolic blood pressures) in MD group (r = -0.50; p < 0.01). More...
nitric oxide (NO)		Stress(stress)	environment	Li HC, 2007	animal model		Nitric oxide contents in prefrontal cortex and hippocampus w...... Nitric oxide contents in prefrontal cortex and hippocampus were significantly higher More...

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