Environment Report

Name	Life events
No. of Studies (Positive/Negative)	9(9/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
life events (LE)	Horesh, 2008	patients and normal controls		The percentage of negative lifetime LE was significantly hig...... The percentage of negative lifetime LE was significantly higher in both MDD and BPD groups than in the control group, while the opposite was true for the percentage of positive LE. More...
Recent life events	Stegenga BT, 2012	nomal people	personal problems (RERI=1.30; 95% CI 0.29 to 2.32); events in family or friends (RERI=1.23; 95% CI 0.28 to 2.19); problems with law (RERI=1.57; 95% CI 0.33 to 2.82)	6910 persons (83.3%) had a complete follow-up, of whom 589 (...... 6910 persons (83.3%) had a complete follow-up, of whom 589 (8.5%) had an onset of MDD (166 younger, 254 middle aged and 169 older). The combined effect of personal problems (RERI=1.30; 95% CI 0.29 to 2.32), events in family or friends (RERI=1.23; 95% CI 0.28 to 2.19), or problems with law (RERI=1.57; 95% CI 0.33 to 2.82) and middle age was larger than the sum of individual effects. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
negative life events		rs6265(rs6265)	SNP	Yang, 2010	patients and normal controls	P-value<0.05	We observed a significant three-way interaction among BDNF r...... We observed a significant three-way interaction among BDNF rs6265, GSK3B rs6782799, and negative life events (corrected P-value, 0.011-0.012; cross-validation consistency, 7; prediction error, 0.4349). More...
negative life events		rs6782799(rs6782799)	SNP	Yang, 2010	patients and normal controls	P-value<0.05	We observed a significant three-way interaction among BDNF r...... We observed a significant three-way interaction among BDNF rs6265, GSK3B rs6782799, and negative life events (corrected P-value, 0.011-0.012; cross-validation consistency, 7; prediction error, 0.4349). More...
negative life events		SLC6A4(5-HTTLPR)	gene	Zhang, 2009	patients and normal controls		The 5-HTTLPR polymorphism was associated with negative life ...... The 5-HTTLPR polymorphism was associated with negative life events on MDD More...
negative life events		BDNF(BDNF)	gene	Yang, 2010	patients and normal controls	P-value<0.05	We observed a significant three-way interaction among BDNF r...... We observed a significant three-way interaction among BDNF rs6265, GSK3B rs6782799, and negative life events (corrected P-value, 0.011-0.012; cross-validation consistency, 7; prediction error, 0.4349). More...
negative life events		GSK3B(GSK3B)	gene	Yang, 2010	patients and normal controls		We observed a significant three-way interaction among BDNF r...... We observed a significant three-way interaction among BDNF rs6265, GSK3B rs6782799, and negative life events (corrected P-value, 0.011-0.012; cross-validation consistency, 7; prediction error, 0.4349). More...
recent life events		Brain-derived neurotrophic factor(BDNF)	protein	Elzinga, 2011	patients only		Exposure to recent life events was associated with decreases...... Exposure to recent life events was associated with decreases in BDNF levels More...
threatening life events		Killer Cells, Natural(Natural killer cell)	cell	Irwin, 1990	patients and normal controls		Both major depressive disorder and the presence of threateni...... Both major depressive disorder and the presence of threatening life events in control subjects are independently associated with a 50% reduction of natural killer (NK) cytotoxicity. More...
major life events		Hippocampus(hippocampus)	brain morphology and function	Kronmuller, 2008	patients and normal controls		A significant negative correlation between major life events...... A significant negative correlation between major life events three month before the onset of depression and the left hippocampal volume was found for male patients. More...
major life events		left hippocampus(left hippocampal volume)	brain morphology and function	Kronmuller, 2008	patients only		A significant negative correlation between major life events...... A significant negative correlation between major life events three month before the onset of depression and the left hippocampal volume was found for male patients. More...
early adverse events		rostral anterior cingulate(rostral ACC)	brain morphology and function	Treadway, 2009	patients and normal controls		Rostral ACC volume was inversely correlated with both cortis...... Rostral ACC volume was inversely correlated with both cortisol and early adverse events. More...
early-life adversity		Hippocampus(hippocampal volumes)	brain morphology and function	Rao, 2010	patients and normal controls		Higher levels of early-life adversity were associated with s...... Higher levels of early-life adversity were associated with smaller hippocampal volumes.Smaller hippocampal volume partially mediated the effect of early-life adversity on depression during longitudinal follow-up. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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