Brain Morphology and Function Report

Name	Hypothalamus
Brain Morphology	The hypothalamus is located below the thalamus, just above the brain stem. In the terminology of neuroanatomy, it forms the ventral part of the diencephalon. The hypothalamus is a brain structure composed of distinct nuclei and less anatomically distinct areas. It is found in all vertebrate nervous systems.
Brain Function	The hypothalamus is involved in functions including homeostasis, emotion, thirst, hunger, circadian rhythms, and control of the autonomic nervous system. In addition, it controls the pituitary.
Picture	From Wiki.
No. of Studies (Positive/Negative)	3(3/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
hypothalamus	Holsen, 2011	patients and normal controls		fMRI results showed greater BOLD signal intensity changes in...... fMRI results showed greater BOLD signal intensity changes in controls versus MDD in hypothalamus, amygdala, hippocampus, OFC, ACC, and subgenual ACC, findings unrelated to medication status. More...
hypothalamus	Hsu, 2012	patients and normal controls		Among A-carriers, BOLD signal was smaller in MDD (n = 7) com...... Among A-carriers, BOLD signal was smaller in MDD (n = 7) compared with controls (n = 50) in the hypothalamus, bilateral amygdala, and left nucleus accumbens. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
hypothalamus		Estradiol(estradiol)	molecule	Holsen, 2011	patients and normal controls		Hypoactivations in hypothalamus, subgenual ACC, amygdala and...... Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. More...
hypothalamus		Progesterone(progesterone)	molecule	Holsen, 2011	patients and normal controls		Hypoactivations in hypothalamus, subgenual ACC, amygdala and...... Hypoactivations in hypothalamus, subgenual ACC, amygdala and OFC in MDD were associated with low estradiol and high progesterone. More...
hypothalamus		Suicide(suicide)	symptoms	Poulter, 2008	patients only		The DNMT gene transcripts' expression was altered in several...... The DNMT gene transcripts' expression was altered in several brains regions of suicides, including frontopolar cortex, amygdala, and the paraventricular nucleus of the hypothalamus. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web