Pathway Report

Name	Focal adhesion
KEGG Link	ID: hsa04510 Name: focal adhesion Brief Description: Focal adhesion Full Description: Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Focal adhesion	Kao CF, 2012	patients and normal controls		We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
LAMC1	laminin, gamma 1 (formerly LAMB2)	Protein mapped	0(0/0)
VTN	vitronectin	Protein mapped	0(0/0)
CCND1	cyclin D1	Literature-origin	1(1/0)
RHOA	ras homolog family member A	Literature-origin	1(1/0)
MYL10	myosin, light chain 10, regulatory	Literature-origin	1(1/0)
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	Literature-origin	1(1/0)
GSK3B	glycogen synthase kinase 3 beta	Literature-origin; SNP mapped; Protein mapped	7(6/1)
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	Literature-origin	1(1/0)
PRKCG	protein kinase C, gamma	SNP mapped	0(0/0)
COL6A1	collagen, type VI, alpha 1	Protein mapped	0(0/0)
JUN	jun proto-oncogene	Literature-origin	1(1/0)
PRKCB	protein kinase C, beta	Protein mapped	0(0/0)
EGF	epidermal growth factor	Literature-origin; SNP mapped; Protein mapped	1(0/1)
COMP	cartilage oligomeric matrix protein	Literature-origin	1(1/0)
ITGB5	integrin, beta 5	Literature-origin	1(1/0)
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Literature-origin	1(1/0)
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	Protein mapped	0(0/0)
MAPK1	mitogen-activated protein kinase 1	Literature-origin	2(2/0)
MAPK8	mitogen-activated protein kinase 8	Literature-origin	1(1/0)
ACTN4	actinin, alpha 4	Protein mapped	0(0/0)
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	Protein mapped	0(0/0)
VEGFA	vascular endothelial growth factor A	Literature-origin	1(1/0)