Study Report
Reference
| Citation | Serretti, 2004 PubMed |
| Full Info | Serretti, A., Mandelli, L., Lattuada, E. and Smeraldi, E. (2004) Depressive syndrome in major psychoses: a study on 1351 subjects. Psychiatry Res, 127, 85-99.
|
Study
| Hypothesis or Background |
The aim of this study was to investigate depressive symptomatology across distinct major psychiatric disorders.
|
| Sample Information | A total of 1351 subjects affected by major depressive disorder (MDD = 389), bipolar disorder (BP = 511), delusional disorder (DD = 93) and schizophrenia (SKZ = 358) were included in our study. |
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| Method Detail | Subjects were assessed using the Operational Criteria for Psychotic Illness checklist (OPCRIT). |
| Method Keywords | clinical test |
| Result | The most frequently represented depressive symptoms in MDD were Loss of energy/tiredness, Loss of pleasure, Poor concentration, and Sleep disorders. Compared with MDD, BP had higher occurrences of Agitated activity, Excessive sleep, and Increased appetite and/or Weight gain, as well as lower Loss of pleasure. In our sample, 32.3% and 26.8% of DD and SKZ, respectively, had quite consistent depressive symptomatology, with at least four or more depressive symptoms. The most common depressive symptoms were Sleep disorders, Poor concentration and Loss of energy/Tiredness, followed by Psychomotor symptoms in SKZ only. Excessive self-reproach, Suicidal ideation, and Appetite and/or Weight changes were more specific to mood disorders. Finally, compared with SKZ, DD suffered from more depressive symptoms and had more severe depressive symptomatology. |
| Conclusions | A quite consistent level of depressive symptomatology is therefore present in subpopulations of delusional and schizophrenic subjects other than in affective subjects. We identified some symptoms that are common across all major psychoses and symptoms that are more specific to each group. |
Relationships reported by
Serretti, 2004
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Fatigue (tiredness) |
symptoms |
|
The most frequently represented depressive symptoms in MDD were Loss of energy/tiredness, Loss of pleasure, Poor concentration, and Sleep disorders. |
Positive
|
|
MDD
|
syndrome |
Low energy (loss of energy) |
symptoms |
|
The most frequently represented depressive symptoms in MDD were Loss of energy/tiredness, Loss of pleasure, Poor concentration, and Sleep disorders. |
Positive
|
|
MDD
|
syndrome |
Attention (poor concentration) |
cognition and behavior |
|
The most frequently represented depressive symptoms in MDD were Loss of energy/tiredness, Loss of pleasure, Poor concentration, and Sleep disorders. |
Positive
|
|
MDD
|
syndrome |
Sleep disturbances (sleep disorders) |
symptoms |
|
The most frequently represented depressive symptoms in MDD were Loss of energy/tiredness, Loss of pleasure, Poor concentration, and Sleep disorders. |
Positive
|
|
MDD
|
syndrome |
Anhedonia (loss of pleasure) |
symptoms |
|
The most frequently represented depressive symptoms in MDD were Loss of energy/tiredness, Loss of pleasure, Poor concentration, and Sleep disorders. |
Positive
|
