Study Report
Reference
| Citation | Yang, 2011 PubMed |
| Full Info | Yang, W., Zhu, X., Wang, X., Wu, D. and Yao, S. (2011) Time course of affective processing bias in major depression: An ERP study. Neurosci Lett, 487, 372-377.
|
Study
| Hypothesis or Background |
|
| Sample Information | major depressive disorder patients |
|---|
| Method Detail | The current study investigated the time course of the affective processing bias in major depressive disorder (MDD) in a visual three-stimulus semantic oddball task using event-related potentials (ERPs). |
| Method Keywords | event-related potential (ERP) |
| Result | MDD patients showed decreased P1 latency over right posterior regions to negative relative to positive target stimuli, reflecting a very early onset of the negativity bias in emotional perception. Compared to controls, MDD patients showed enlarged anterior P2 amplitude to positive target stimuli, reflecting an affective bias in the early attentional stages of processing. In addition, MDD patients showed relatively high N2 and reduced P3 amplitudes to negative compared with positive target stimuli, as well as marginally reduced N2 amplitude to positive target stimuli compared with controls. |
| Conclusions | This suggests that the negativity bias also occurs during later strategic evaluation stages. Therefore, the present study extended previous findings by demonstrating that the affective processing bias in MDD begins in the early stages of perceptual processing and continues at later cognitive stages. |
Relationships reported by
Yang, 2011
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
P300 (P3) |
neurobiological system |
|
MDD patients showed reduced P3 amplitudes to negative compared with positive target stimuli. |
Positive
|
|
MDD
|
syndrome |
Cognitive processing bias (affective processing bias) |
cognition and behavior |
|
The present study extended previous findings by demonstrating that the affective processing bias in MDD begins in the early stages of perceptual processing and continues at later cognitive stages. |
Positive
|
|
MDD
|
syndrome |
Cognitive processing bias (affective bias) |
cognition and behavior |
|
Compared to controls, MDD patients showed enlarged anterior P2 amplitude to positive target stimuli, reflecting an affective bias in the early attentional stages of processing. |
Positive
|
|
Cognitive processing bias (negativity bias in emotional perception)
|
cognition and behavior |
P100 (P1) |
neurobiological system |
|
MDD patients showed decreased P1 latency over right posterior regions to negative relative to positive target stimuli, reflecting a very early onset of the negativity bias in emotional perception. |
Positive
|
|
MDD
|
syndrome |
Cognitive processing bias (negativity bias in emotional perception) |
cognition and behavior |
|
MDD patients showed decreased P1 latency over right posterior regions to negative relative to positive target stimuli, reflecting a very early onset of the negativity bias in emotional perception. |
Positive
|
|
MDD
|
syndrome |
N200 (N2) |
neurobiological system |
|
MDD patients showed relatively high N2 amplitudes to negative compared with positive target stimuli. MDD patients showed marginally reduced N2 amplitude to positive target stimuli compared with controls. |
Positive
|
|
Cognitive processing bias (affective bias)
|
cognition and behavior |
P200 (P2) |
neurobiological system |
|
Compared to controls, MDD patients showed enlarged anterior P2 amplitude to positive target stimuli, reflecting an affective bias in the early attentional stages of processing. |
Positive
|
|
MDD
|
syndrome |
P200 (P2) |
neurobiological system |
|
Compared to controls, MDD patients showed enlarged anterior P2 amplitude to positive target stimuli. |
Positive
|
|
MDD
|
syndrome |
P100 (P1) |
neurobiological system |
|
MDD patients showed decreased P1 latency over right posterior regions to negative relative to positive target stimuli |
Positive
|
