Study Report
Reference
| Citation | Yang, 2010 PubMed |
| Full Info | Yang, C., Xu, Y., Sun, N., Ren, Y., Liu, Z., Cao, X. and Zhang, K. (2010) The combined effects of the BDNF and GSK3B genes modulate the relationship between negative life events and major depressive disorder. Brain Res, 1355, 1-6.
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Study
| Hypothesis or Background |
For major depressive disorder (MDD), BDNF and GSK3B are logical candidate genes and an interaction between BDNF polymorphism and negative life events has been observed. Our previous study revealed that a gene-gene interaction among BDNF and GSK3B may confer the risk of MDD. In the present study, we hypothesized a gene-environment interaction between the BDNF-GSK3B combination and negative life events in the risk for developing MDD.
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| Sample Information | 404 patients with MDD and 388 age- and gender-matched control subjects |
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| Method Detail | To test this hypothesis, we conducted a case-control study in a northern Han Chinese population. A total of 404 patients with MDD and 388 age- and gender-matched control subjects were recruited. Negative life events and objective social supports were assessed using standard rating scales. Three polymorphisms of BDNF and GSK3B genes were identified by sequencing. Gene-environment interactions were analyzed by generalized multifactor dimensionality reduction (GMDR). |
| Method Keywords | genotyping; psychometric method |
| Result | Under a dominant model, we observed a potential association between the GSK3B rs6782799 and MDD (P=0.07), a significant three-way interaction among BDNF rs6265, GSK3B rs6782799, and negative life events (corrected P-value, 0.011-0.012; cross-validation consistency, 7; prediction error, 0.4349). |
| Conclusions | To our knowledge, this is the first report of evidence that the BDNF-GSK3B interaction may modify the relationship between negative life events and MDD in the Chinese population. |
Relationships reported by
Yang, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
Life events (negative life events)
|
environment |
BDNF (BDNF) |
gene |
P-value<0.05 |
We observed a significant three-way interaction among BDNF rs6265, GSK3B rs6782799, and negative life events (corrected P-value, 0.011-0.012; cross-validation consistency, 7; prediction error, 0.4349). |
Positive
|
|
MDD
|
syndrome |
GSK3B (GSK3B) |
gene |
P-value=0.07 |
We observed a potential association between the GSK3B rs6782799 and MDD (P=0.07) |
Positive
|
|
Life events (negative life events)
|
environment |
GSK3B (GSK3B) |
gene |
|
We observed a significant three-way interaction among BDNF rs6265, GSK3B rs6782799, and negative life events (corrected P-value, 0.011-0.012; cross-validation consistency, 7; prediction error, 0.4349). |
Positive
|
|
Life events (negative life events)
|
environment |
rs6782799 (rs6782799) |
SNP |
P-value<0.05 |
We observed a significant three-way interaction among BDNF rs6265, GSK3B rs6782799, and negative life events (corrected P-value, 0.011-0.012; cross-validation consistency, 7; prediction error, 0.4349). |
Positive
|
|
Life events (negative life events)
|
environment |
rs6265 (rs6265) |
SNP |
P-value<0.05 |
We observed a significant three-way interaction among BDNF rs6265, GSK3B rs6782799, and negative life events (corrected P-value, 0.011-0.012; cross-validation consistency, 7; prediction error, 0.4349). |
Positive
|
|
MDD
|
syndrome |
rs6782799 (rs6782799) |
SNP |
P-value<0.05 |
We observed a potential association between the GSK3B rs6782799 and MDD (P=0.07) |
Positive
|
