Study Report
Reference
| Citation | Pedrelli, 2010 PubMed |
| Full Info | Pedrelli, P., Baer, L., Losifescu, D.V. and Fava, M. (2010) Relationship between residual symptoms of depression and self-reported cognitive impairment. CNS Spectr, 15, 46-51.
|
Study
| Hypothesis or Background |
The present study aimed to investigate the associations between residual symptoms of depression and specific self-reported symptoms in several cognitive domains.
|
| Sample Information | 117 patients with partially or fully remitted major depressive disorder (MDD) |
|---|
| Method Detail | The study investigated 117 patients with partially or fully remitted major depressive disorder (MDD) after treatment with antidepressant medications. |
| Method Keywords | clinical test |
| Result | Fatigue was significantly associated with inability to focus, alertness, and feeling blue; low interest and difficulty with concentration were associated with apathy. No associations were found between deficits in the cognitive domains considered and residual symptoms such as self-blaming, feeling worthless, feeling hopeless, having suicidal thoughts, difficulty with sleep, and lack of appetite. |
| Conclusions | Among MDD remitted patients endorsing residual symptoms such as fatigue and feeling blue, deficits in a range of cognitive domains should be carefully assessed and treated. |
Relationships reported by
Pedrelli, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
Fatigue (fatigue)
|
symptoms |
Alertness (alertness) |
cognition and behavior |
|
Fatigue was significantly associated with inability to focus, alertness, and feeling blue |
Positive
|
|
Fatigue (fatigue)
|
symptoms |
Attention (inability to focus) |
cognition and behavior |
|
Fatigue was significantly associated with inability to focus, alertness, and feeling blue |
Positive
|
|
Fatigue (fatigue)
|
symptoms |
Depressed mood (feeling blue) |
symptoms |
|
Fatigue was significantly associated with inability to focus, alertness, and feeling blue |
Positive
|
|
Attention (difficulty with concentration)
|
cognition and behavior |
Apathy (apathy) |
symptoms |
|
Low interest and difficulty with concentration were associated with apathy |
Positive
|
|
Anhedonia (low interest)
|
symptoms |
Apathy (apathy) |
symptoms |
|
Low interest and difficulty with concentration were associated with apathy |
Positive
|
