KEGG Pathway Report
Basic Information
| ID |
hsa04260
|
| Name |
cardiac muscle_contraction
|
| Brief Description |
Cardiac muscle contraction
|
| Full Description |
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR. |
hsa04260 related genes in MK4MDD (count: 12)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| ATP1A4 |
ATPase, Na+/K+ transporting, alpha 4 polypeptide |
Protein mapped
|
0(0/0) |
| CACNA1C |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
Literature-origin
|
2(1/1) |
| CACNG3 |
calcium channel, voltage-dependent, gamma subunit 3 |
Literature-origin
|
1(1/0) |
| COX7A2 |
cytochrome c oxidase subunit VIIa polypeptide 2 (liver) |
Protein mapped
|
0(0/0) |
| RYR2 |
ryanodine receptor 2 (cardiac) |
Literature-origin
|
1(1/0) |
| COX4I1 |
cytochrome c oxidase subunit IV isoform 1 |
Protein mapped
|
0(0/0) |
| ATP1A3 |
ATPase, Na+/K+ transporting, alpha 3 polypeptide |
Literature-origin; Protein mapped
|
1(1/0) |
| ATP1B2 |
ATPase, Na+/K+ transporting, beta 2 polypeptide |
Literature-origin
|
1(1/0) |
| ATP1A2 |
ATPase, Na+/K+ transporting, alpha 2 polypeptide |
Protein mapped
|
0(0/0) |
| TPM2 |
tropomyosin 2 (beta) |
Literature-origin
|
1(1/0) |
| COX5B |
cytochrome c oxidase subunit Vb |
Protein mapped
|
0(0/0) |
| ATP1A1 |
ATPase, Na+/K+ transporting, alpha 1 polypeptide |
Protein mapped
|
0(0/0) |
