MK4MDD

KEGG Pathway Report

Basic Information
ID hsa04260
Name cardiac muscle_contraction
Brief Description Cardiac muscle contraction
Full Description Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.

hsa04260 related genes in MK4MDD (count: 12)
Approved Symbol Approved Name Type No. of Studies (Positive/Negative)
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide Protein mapped 0(0/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit Literature-origin 2(1/1)
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 Literature-origin 1(1/0)
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) Protein mapped 0(0/0)
RYR2 ryanodine receptor 2 (cardiac) Literature-origin 1(1/0)
COX4I1 cytochrome c oxidase subunit IV isoform 1 Protein mapped 0(0/0)
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide Literature-origin; Protein mapped 1(1/0)
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide Literature-origin 1(1/0)
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide Protein mapped 0(0/0)
TPM2 tropomyosin 2 (beta) Literature-origin 1(1/0)
COX5B cytochrome c oxidase subunit Vb Protein mapped 0(0/0)
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide Protein mapped 0(0/0)