Gene Report

Basic Information

Approved Symbol	ATP1B2
Approved Name	ATPase, Na+/K+ transporting, beta 2 polypeptide
Symbol Alias	AMOG
Name Alias	"sodium/potassium-transporting ATPase subunit beta-2", "sodium pump subunit beta-2", "sodium-potassium ATPase subunit beta 2 (non-catalytic)"
Location	17p13.1
Position	chr17:7559214-7561089 (+)
External Links	Entrez Gene: 482 Ensembl: ENSG00000129244 UCSC: uc002gif.1 HGNC ID: 805
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ATP1B2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
ATP1B2	Sequeira, 2007	patients and normal controls		Selected differentially expressed genes in hippocampus Selected differentially expressed genes in hippocampus

Positive relationships between ATP1B2 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
ATP1B2		Hippocampus(hippocampus)	brain morphology and function	Sequeira, 2007	patients and normal controls		Selected differentially expressed genes in hippocampus Selected differentially expressed genes in hippocampus

Positive relationship network of ATP1B2 in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ATP1B2 and MDD (count: 0)

Negative relationships between ATP1B2 and other components at different levels (count: 0)

ATP1B2 related SNPs in MK4MDD (count: 0)

ATP1B2 related proteins in MK4MDD (count: 0)

ATP1B2 related GO terms (count: 29)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0051117	ATPase binding	molecular function	IPI[10636900]
GO:0005886	plasma membrane	cellular component	TAS
GO:0016324	apical plasma membrane	cellular component	IEA
GO:0090662	ATP hydrolysis coupled transmembrane transport	biological process	IDA[10636900\|19542013]; IEA; TAS[2538450]
GO:0086064	cell communication by electrical coupling involved in cardiac conduction	biological process	TAS[19683723]
GO:0006883	cellular sodium ion homeostasis	biological process	IDA[10636900\|19542013]
GO:0007155	cell adhesion	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[11027149]
GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	biological process	IDA[10636900\|19542013]; IEA; TAS[2538450]
GO:0010107	potassium ion import	biological process	IDA[10636900\|19542013]
GO:0001671	ATPase activator activity	molecular function	IDA[10636900]
GO:0036376	sodium ion export from cell	biological process	IDA[10636900\|19542013]
GO:0055085	transmembrane transport	biological process	TAS
GO:0050821	protein stabilization	biological process	IDA[10636900]
GO:0086009	membrane repolarization	biological process	IDA[19542013]
GO:1901018	positive regulation of potassium ion transmembrane transporter activity	biological process	IDA[10636900]
GO:0007596	blood coagulation	biological process	TAS
GO:1903278	positive regulation of sodium ion export from cell	biological process	IDA[10636900]
GO:0005890	sodium:potassium-exchanging ATPase complex	cellular component	IDA[10636900\|19542013]
GO:0030007	cellular potassium ion homeostasis	biological process	IDA[10636900\|19542013]
GO:0061337	cardiac conduction	biological process	TAS
GO:1903779	regulation of cardiac conduction	biological process	TAS
GO:0005391	sodium:potassium-exchanging ATPase activity	molecular function	IDA[19542013]; IDA[10636900]
GO:0034220	ion transmembrane transport	biological process	TAS
GO:1903288	positive regulation of potassium ion import	biological process	IDA[10636900]
GO:0006810	transport	biological process	TAS[2538450]
GO:0050900	leukocyte migration	biological process	TAS
GO:0032781	positive regulation of ATPase activity	biological process	IDA[10636900]
GO:0005737	cytoplasm	cellular component	IEA

ATP1B2 related KEGG pathways (count: 3)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04960	aldosterone regulated_sodium_reabsorption	Aldosterone-regulated sodium reabsorption	Sodium transport across the tight epithelia of Na+ reabsorbi...... Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-term blood pressure. Aldosterone plays a major role in sodium and potassium metabolism by binding to epithelial mineralocorticoid receptors (MR) in the renal collecting duct cells localized in the distal nephron, promoting sodium resorption and potassium excretion. Aldosterone enters a target cell and binds MR, which translocates into the nucleus and regulates gene transcription. Activation of MR leads to increased expression of Sgk-1, which phosphorylates Nedd4-2, an ubiquitin-ligase which targets ENAC to proteosomal degradation. Phosphorylated Nedd4-2 dissociates from ENAC, increasing its apical membrane abundance. Activation of MR also leads to increased expression of Na+/K+-ATPase, thus causing a net increase in sodium uptake from the renal filtrate. The specificity of MR for aldosterone is provided by 11beta-HSD2 by the rapid conversion of cortisol to cortisone in renal cortical collecting duct cells. Recently, besides genomic effects mediated by activated MR, rapid aldosterone actions that are independent of translation and transcription have been documented. More...
hsa04260	cardiac muscle_contraction	Cardiac muscle contraction	Contraction of the heart is a complex process initiated by t...... Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR. More...
hsa04964	proximal tubule_bicarbonate_reclamation	Proximal tubule bicarbonate reclamation	One of the major tasks of the renal proximal tubule (PT) is ...... One of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating new HCO3(-) for regulating blood pH. In the tubular lumen, filtered HCO3(-) combines with H(+) in a reaction catalyzed by CA IV. The CO2 thus produced rapidly diffuses into the tubular cells and is combined with water to produce intracellular H(+) and HCO3(-), catalyzed by soluble cytoplasmic CA II. HCO3(-) is then cotransported with Na(+) into blood via the NBC-1. The intracellular H(+) produced by CA II is secreted into the tubular lumen predominantly via the NHE-3. The PT creates the new HCO3(-) by taking glutamine and metabolizing it to two molecules each of NH4(+) and HCO3(-). The NH4(+) is excreted into the tubular lumen, and the HCO3(-) , which is new HCO3(-) , is returned to the blood, where it replaces the HCO3(-) lost earlier in the titration of nonvolatile acids. More...

ATP1B2 related BioCarta pathways (count: 0)

ATP1B2 related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_604	hemostasis	Two principal mechanisms limit blood loss after vascular inj...... Two principal mechanisms limit blood loss after vascular injury. Initially, platelets are activated, adhere to the site of the injury, and aggregate into a plug that limits blood loss. Proteins and small molecules released from activated platelets stimulate the plug formation process, and fibrinogen from the plasma forms bridges between activated platelets. These events allow the initiation of the clotting cascade, the second mechanism to limit blood loss. Negatively charged phospholipids exposed on cell surfaces at the site of injury and on activated platelets interact with tissue factor, setting off a cascade of reactions leading to generation of fibrin and the formation of an insoluble fibrin clot that strengthens the platelet plug. More...
REACT_6900	signaling in_immune_system	Humans are exposed to millions of potential pathogens daily,...... Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system. More...
REACT_12560	basigin interactions	Basigin is a widely expressed transmembrane glycoprotein tha...... Basigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interactions involved in various immunologic phenomena, differentiation, and development, but a major function of basigin is stimulation of synthesis of several matrix metalloproteinases. Basigin also induces angiogenesis via stimulation of VEGF production. Basigin has an extracellular region with two Ig-like domains of which the N-term Ig-like domain is involved in interactions. It undergoes interactions between basigin molecules on opposing cells or on neighbouring cells. It also interacts with a variety of other proteins like caveolin-1, cyclophilins, integrins and annexin II that play important roles in cell proliferation, energy metabolism, migration, adhesion and motion, especially in cancer metastasis. More...
REACT_12051	cell surface_interactions_at_the_vascular_wall	Leukocyte extravasation is a rigorously controlled process t...... Leukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are required for leukocytes to withstand local flow at the vessel wall is a multistep process mediated by different adhesion molecules. Platelets adhered to injured vessel walls form strong adhesive substrates for leukocytes. For instance, the initial tethering and rolling of leukocytes over the site of injury are mediated by reversible binding of selectins to their cognate cell-surface glycoconjugates. Endothelial cells are tightly connected through various proteins, which regulate the organization of the junctional complex and bind to cytoskeletal proteins or cytoplasmic interaction partners that allow the transfer of intracellular signals. An important role for these junctional proteins in governing the transendothelial migration of leukocytes under normal or inflammatory conditions has been established. This pathway describes some of the key interactions that assist in the process of platelet and leukocyte interaction with the endothelium, in response to injury. More...

ATP1B2 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways