Pathway Report

Basic Information

Name	synaptic transmission, glutamatergic
GO Link	ID: GO:0035249 Name: synaptic transmission, glutamatergic Type: biological process
Description	biological_process. The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.[GOC:kmv]
No. of Studies (Positive/Negative)	2 (2/0)

Positive relationship between synaptic transmission, glutamatergic and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
glutamatergic neurotransmission	Rosenberg, 2004	patients and normal controls		Anterior cingulate glutamatergic concentrations were signifi...... Anterior cingulate glutamatergic concentrations were significantly reduced in patients with MDD. More...

Positive relationships between synaptic transmission, glutamatergic and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
glutamatergic activity		Aldosterone(aldosterone)	molecule	Hlavacova, 2011	animal model		Aldosterone treatment resulted in transcriptional changes of...... Aldosterone treatment resulted in transcriptional changes of genes in the hippocampus involved in glutamatergic activity. More...

Positive relationship network of synaptic transmission, glutamatergic in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between synaptic transmission, glutamatergic and MDD (count: 0)

Negative relationships between synaptic transmission, glutamatergic and other components at different levels (count: 0)

Pathway synaptic transmission, glutamatergic related genes in MK4MDD (count: 4)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
GRID2	glutamate receptor, ionotropic, delta 2	Literature-origin	1(1/0)
GRIK5	glutamate receptor, ionotropic, kainate 5	Literature-origin	1(1/0)
SLC17A7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	Literature-origin; Protein mapped	4(4/0)
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	Literature-origin	1(1/0)