Brain Morphology and Function Report

Name	right hippocampus
Brain Morphology	Please reference to the description for Hippocampus
No. of Studies (Positive/Negative)	10(10/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
right hippocampus	Aihara, 2007	patients only		Prior to treatment of the unmedicated MDD, a significant hyp...... Prior to treatment of the unmedicated MDD, a significant hypermetabolism in the right hippocampus were observed compared with controls. More...
right hippocampus	MacMaster, 2004	patients and normal controls	P-value = 0.047	An analysis of covariance revealed a significant difference ...... An analysis of covariance revealed a significant difference between MDD and control subjects (F = 8.66, df = 1, 29, P = 0.006). This was more strongly localized to the left hippocampus (P = 0.001) than the right hippocampus (P = 0.047). Our findings provide new evidence of abnormalities in the hippocampus in early onset depression. More...
right hippocampal volumes	Frodl, 2004	patients and normal controls		The right hippocampal volumes of nonremitted patients were s...... The right hippocampal volumes of nonremitted patients were significantly smaller compared with matched healthy controls. More...
right hippocampal volume	O'Brien, 2004	patients and normal controls	53% increase; 6% decrease	Depressed subjects had hypercortisolemia (53% increase in ar...... Depressed subjects had hypercortisolemia (53% increase in area under the curve) and a reduction in right hippocampal volume (6% decrease). More...
right hippocampus	Lee, 2007	patients and normal controls		Depressed individuals demonstrated lower activity in the rig...... Depressed individuals demonstrated lower activity in the right hippocampus to negative affective pictures. More...
right hippocampus	Cole, 2010	patients and normal controls	P-value = 0.016	while only the right hippocampus (P=0.016) showed a reduced ...... while only the right hippocampus (P=0.016) showed a reduced volume in a subgroup of first-episode depression patients (n=13) relative to healthy controls More...
right hippocampus	Malykhin, 2010	patients and normal controls		We found a significant reduction in the volume of the hippoc...... We found a significant reduction in the volume of the hippocampal tail bilaterally, right hippocampal head and right total hippocampus in MDD patients. More...
right hippocampus	Nifosi, 2010	patients and normal controls		Volumes of the right hippocampal body and tail were signific...... Volumes of the right hippocampal body and tail were significantly smaller in female patients with familial depressive disorder than in healthy subjects. More...
right hippocampal grey	Amico, 2011	patients and high-risk people and normal controls		The HC-FHP(healthy controls with a positive family history f...... The HC-FHP(healthy controls with a positive family history for MDD) group had smaller right hippocampal and DLPFC grey matter volumes compared with the HC-FHN(healthy controls with no family history of any psychiatric disease) group, and even smaller right hippocampal volumes compared with patients with MDD. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
right hippocampus		SLC6A4(serotonin transporter gene (5-HTTLPR))	gene	Frodl, 2008	patients and normal controls		We found that healthy controls have a strong association bet...... We found that healthy controls have a strong association between the 5-HTTLPR and GM (gray matter) volumes of the right hippocampus, whereas there is no such association in patients with major depression. Healthy subjects carrying the S- or L(G)-allele have smaller GM volumes than those with the L(A)-allele More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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3. The network is generated using Cytoscape Web