Pathway Report

Basic Information

Name	kinase activity
GO Link	ID: GO:0016301 Name: kinase activity Type: molecular function
Description	Genes annotated by the GO term GO:0016301. Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
No. of Studies (Positive/Negative)	1 (1/0)

Positive relationship between kinase activity and MDD (count: 0)

Positive relationships between kinase activity and other components at different levels (count: 2)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
Kinase activity		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Tordera RM, 2011	animal model	genes invovled in this pathwy were regulated in frontal cort...... genes invovled in this pathwy were regulated in frontal cortex of VGLUT1(+/-) mice More...
Kinase activity		Stress(stress)	environment	Tordera RM, 2011	animal model	After CMS, Specifically, a dowregulation in genes that promo...... After CMS, Specifically, a dowregulation in genes that promote cell proliferation (Anapc7), cell growth (CsnK1g1), cell survival (Hdac3), and inhibition of apoptosis (Dido1) was observed. Genes linked to cytoskeleton (Hspg2, Invs), psychiatric disorders (Grin1, MapK12) or an antioxidant enzyme (Gpx2) were also downregulated. Moreover, genes that inhibit the MAPK pathways (Dusp14), stimulate oxidative metabolism (Eif4a2) and enhance glutamate transmission (Rab8b) were upregulated. More...

Positive relationship network of kinase activity in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between kinase activity and MDD (count: 0)

Negative relationships between kinase activity and other components at different levels (count: 0)

Pathway kinase activity related genes in MK4MDD (count: 2)

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
GSK3B	glycogen synthase kinase 3 beta	Literature-origin; SNP mapped; Protein mapped	7(6/1)
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	Literature-origin; Protein mapped	1(1/0)