Molecule Report

Name	gamma-Aminobutyric Acid
Description	The most common inhibitory neurotransmitter in the central nervous system.
MeSH ID	D005680
No. of Studies (Positive/Negative)	11(11/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
gamma-aminobutyric acid (GABA)	Sanacora, 2004	patients and normal controls	P-value=0.01	Depressed subjects had significantly lower occipital cortex ...... Depressed subjects had significantly lower occipital cortex GABA concentrations compared with healthy controls (P =.01). More...
gamma-aminobutyric acid (GABA)	Hasler, 2005	patients and normal controls		Secondary analyses provided preliminary evidence for a negat...... Secondary analyses provided preliminary evidence for a negative relationship between the glutamate/glutamine (Glx)/GABA ratio and age of onset of major depression in the ventromedial prefrontal cortex. More...
gamma-aminobutyric acid (GABA)	Bajbouj, 2006	patients and normal controls		Silent period and intracortical inhibition were reduced in d...... Silent period and intracortical inhibition were reduced in depressed patients, consistent with a reduced GABAergic tone. More...
gamma-aminobutyric acid (GABA)	Bhagwagar, 2007	patients and normal controls		Occipital levels of GABA and NAA were significantly lower in...... Occipital levels of GABA and NAA were significantly lower in recovered depressed and bipolar subjects than in healthy controls, whereas Glu +Gln concentrations were higher. More...
gamma-aminobutyric acid (GABA)	Bhagwagar, 2008	patients only		Levels of GABA in both occipital and anterior cingulate cort...... Levels of GABA in both occipital and anterior cingulate cortex were significantly lower in recovered depressed subjects than healthy controls. More...
gamma-aminobutyric acid	Block, 2009	patients and normal controls		In the cross-sectional comparison, we observed a significant...... In the cross-sectional comparison, we observed a significant reduction of the metabolic ratios Glx/Cr (Glx=glutamine, glutamate and gamma-aminobutyric acid) and glutamine (Gln)/Cr in the patient group. More...
gamma-aminobutyric acid (GABA)	Price, 2009	patients and normal controls	P-value = .007; Cohen's d = 1.4	Levels of OCC(occipital cortex) GABA relative to voxel tissu...... Levels of OCC(occipital cortex) GABA relative to voxel tissue water (W) were decreased in TRD(treatment-resistant depression) patients compared with both HV(healthy volunteers) (20.2% mean reduction; p = .001; Cohen's d = 1.3) and nTRD(nontreatment-resistant MDD) subjects (16.4% mean reduction; p = .007; Cohen's d = 1.4). More...
gamma-aminobutyric acid (GABA)	Gabbay, 2012	patients and normal controls	t = 3.2; P-value <0.003	Compared with control subjects, adolescents with MDD had sig...... Compared with control subjects, adolescents with MDD had significantly decreased ACC GABA/w (t = 3.2; P < .003). More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
GABA		SLC17A7(vesicular glutamate transporter 1 (VGLUT1))	gene	Garcia-Garcia AL, 2009	animal model		VGLUT1+/- mice showed decreased GABA VGLUT1+/- mice showed decreased GABA
gamma-aminobutyric acid (GABA)		Prefrontal cortex(prefrontal region)	brain morphology and function	Hasler, 2007	patients and normal controls		The GABA levels were reduced in the dorsomedial/dorsal anter...... The GABA levels were reduced in the dorsomedial/dorsal anterolateral prefrontal ROI. More...
gamma-aminobutyric acid (GABA)		Anhedonia(anhedonia)	symptoms	Gabbay, 2012	patients and normal controls	t = 4.08; P-value < 0.001; P-value(Tukey) <0 .001	When subjects with MDD were categorized based on the presenc...... When subjects with MDD were categorized based on the presence of anhedonia, only anhedonic patients had decreased GABA/w levels compared with control subjects (t = 4.08; P < .001; P(Tukey) < .001). More...
GABA		Stress(stress)	environment	Garcia-Garcia AL, 2009	animal model		CMS induced anhedonia, helplessness, anxiety, and impaired r...... CMS induced anhedonia, helplessness, anxiety, and impaired recognition memory More...
GABA		Stress(stress)	environment	Elizalde N, 2010	animal model		CMS-induced lasting anhedonia and region-specific changes in...... CMS-induced lasting anhedonia and region-specific changes in neuronal activity (c-Fos immunoreactivity) and neurotransmitter (glutamate and GABA) levels More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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