Pathway Report

Name	adenylate cyclase activity
GO Link	ID: GO:0004016 Name: adenylate cyclase activity Type: molecular function
No. of Studies (Positive/Negative)	4 (4/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
adenylyl cyclase	Dowlatshahi, 1999	patients and normal controls		There was no effect of diagnosis on any measure, except for ...... There was no effect of diagnosis on any measure, except for a trend toward decreased stimulated AC activity in subjects with mood disorders relative to control subjects More...
adenylyl cyclase	Hsiung, 2003	patients and normal controls		Measurements of [35S]GTPgammaS binding to Galphai/o in the o...... Measurements of [35S]GTPgammaS binding to Galphai/o in the occipital cortex of suicide victims and matched controls revealed a blunted response in suicide subjects and a decrease in the coupling of 5-HT1A receptor to adenylyl cyclase. More...
adenylate cyclase	Valdizan, 2003	patients and normal controls	P-value<0.01	we found a significant lower response to beta(1)-adrenocepto...... we found a significant lower response to beta(1)-adrenoceptors agonist-stimulated AC(adenylate cyclase) activity in the major depressive disorder group (p <.01). More...
adenylyl cyclase (AC) activity	Valdizan, 2010	patients and normal controls	P-value<0.01	In depressed victims, an increase in [(3)S] GTPgammaS bindin...... In depressed victims, an increase in [(3)S] GTPgammaS binding potency (EC = .58 mumol/L vs. EC = 3.31 mumol/L; p < .01; depressed vs. control) and a significant reduction in the maximal inhibition of AC activity (I(max) = 27 +/- 4% vs. I(max) = 47 +/- 5%; p < .01) were observed after incubation with the alpha(2)-adrenoceptor agonist UK14304. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
adenylyl cyclase		Suicide(suicide)	symptoms	Hsiung, 2003	patients and normal controls		Measurements of [35S]GTPgammaS binding to Galphai/o in the o...... Measurements of [35S]GTPgammaS binding to Galphai/o in the occipital cortex of suicide victims and matched controls revealed a blunted response in suicide subjects and a decrease in the coupling of 5-HT1A receptor to adenylyl cyclase. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
GNAS	GNAS complex locus	Literature-origin	1(0/1)
ADCY7	adenylate cyclase 7	Literature-origin; SNP mapped	2(2/0)
ADCY8	adenylate cyclase 8 (brain)	Literature-origin	2(2/0)
ADCY3	adenylate cyclase 3	Literature-origin; SNP mapped	1(0/1)