Neurobiological Component Report

Name	Theta wave
Description	A theta rhythm is an oscillatory pattern in EEG signals recorded either from inside the brain or from electrodes glued to the scalp. Two types of theta rhythm have been described. The "hippocampal theta rhythm" is a strong oscillation that can be observed in the hippocampus and other brain structures in numerous species of mammals, "Cortical theta rhythms" are low-frequency components of scalp EEG, usually recorded from humans. In human EEG studies, the term theta refers to frequency components in the 4-7 Hz range, regardless of their source. Cortical theta is observed frequently in young children. In older children and adults, it tends to appear during drowsy, meditative, or sleeping states, but not during the deepest stages of sleep.
Picture	From Wiki.
No. of Studies (Positive/Negative)	7 (7/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
theta	Fingelkurts, 2007	patients and normal controls		Some of the functional connections were positively correlate...... Some of the functional connections were positively correlated with the severity of depression, thus being predictive. These were short-range anterior functional connections for the theta frequency band. More...
theta frequency band	Korb, 2008	patients and normal controls		MDD subjects showed significantly elevated current density i...... MDD subjects showed significantly elevated current density in delta, theta, alpha, beta1, and beta2 frequency bands relative to controls in anterior cingulate and prefrontal cortices. More...
theta-band cordance	Cook, 2009	patients only		Decreases in MRF (midline and right frontal cortical area) c...... Decreases in MRF (midline and right frontal cortical area) cordance at 1 week predicted remission with medication with 69% overall accuracy (90% sensitivity; 60% specificity). More...
theta	Cornwell, 2010	patients and normal controls		Robust group differences in theta activity were observed in ...... Robust group differences in theta activity were observed in right medial temporal cortices during navigation, with patients exhibiting less engagement of the anterior hippocampus and parahippocampal cortices relative to comparison subjects. More...
theta	Kohler, 2011	patients and normal controls	P-value = 0.015	Compared with healthy controls, patients had more theta acti...... Compared with healthy controls, patients had more theta activity (p = 0.015) More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
theta		Rapid eye movement (REM) sleep(rapid eye movement (REM) sleep)	neurobiological system	Liscombe, 2002	patients and normal controls		In general, slower frequencies declined across REM periods, ...... In general, slower frequencies declined across REM periods, with a significant REM period effect for delta, theta and alpha amplitude. More...
theta		Functional connectivity(short-range anterior functional connections)	brain morphology and function	Fingelkurts, 2007	patients and normal controls		Some of the functional connections were positively correlate...... Some of the functional connections were positively correlated with the severity of depression, thus being predictive. These were short-range anterior functional connections for the theta frequency band More...
theta		Suicide(suicidal ideation (SI))	symptoms	Iosifescu, 2008	patients only		Left-right asymmetry of combined theta + alpha power correla...... Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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