Study Report
Reference
| Citation | Liscombe, 2002 PubMed |
| Full Info | Liscombe, M.P., Hoffmann, R.F., Trivedi, M.H., Parker, M.K., Rush, A.J. and Armitage, R. (2002) Quantitative EEG amplitude across REM sleep periods in depression: preliminary report. J Psychiatry Neurosci, 27, 40-46.
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Study
| Hypothesis or Background |
To determine if there are significant differences in the temporal organization of rapid eye movement (REM) sleep microarchitecture between healthy controls and outpatients with major depressive disorder (MDD).
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| Sample Information | forty age-matched subjects, 20 men and 20 women, half with MDD |
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| Method Detail | Forty age-matched subjects, 20 men and 20 women, half with MDD, were selected from an archive of sleep electroencephalography (EEG) data collected under identical conditions. Each participant spent 2 consecutive nights in the Sleep Study Unit of the University of Texas Southwestern Medical Center at Dallas, the first of which served as adaptation. The average amplitude in each of 5 conventional EEG frequency bands was computed for each REM period across the second night. Data were then coded for group and sex. |
| Method Keywords | electroencephalogram (EEG) |
| Result | Aside from REM latency, none of the key sleep macroarchitectural variables differentiated MDD patients from controls. REM latency was longest in men with MDD. Sleep microarchitecture, however, did show a number of between-group differences. In general, slower frequencies declined across REM periods, with a significant REM period effect for delta, theta and alpha amplitude. Group x sex interactions were also obtained for theta and alpha. Beta activity showed a unique temporal profile in each group, supported by a significant REM period x group x sex interaction. In addition, the temporal change in theta amplitude across REM periods was most striking in women with MDD. |
| Conclusions | This study suggests that, like during non-REM sleep, EEG amplitude shows a systematic temporal change over successive REM sleep periods and also shows elements that are both disease- and sex-dependent. |
Relationships reported by
Liscombe, 2002
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Rapid eye movement (REM) sleep (rapid eye movement (REM) sleep) |
neurobiological system |
|
Aside from REM latency, none of the key sleep macroarchitectural variables differentiated MDD patients from controls. REM latency was longest in men with MDD. |
Positive
|
|
Rapid eye movement (REM) sleep (rapid eye movement (REM) sleep)
|
neurobiological system |
Delta wave (delta) |
neurobiological system |
|
In general, slower frequencies declined across REM periods, with a significant REM period effect for delta, theta and alpha amplitude. |
Positive
|
|
Rapid eye movement (REM) sleep (rapid eye movement (REM) sleep)
|
neurobiological system |
Theta wave (theta) |
neurobiological system |
|
In general, slower frequencies declined across REM periods, with a significant REM period effect for delta, theta and alpha amplitude. |
Positive
|
|
Rapid eye movement (REM) sleep (rapid eye movement (REM) sleep)
|
neurobiological system |
Alpha wave (alpha) |
neurobiological system |
|
In general, slower frequencies declined across REM periods, with a significant REM period effect for delta, theta and alpha amplitude. |
Positive
|
