Brain Morphology and Function Report

Basic Information

Name	Temporo-parietal connection
Brain Morphology	The temporo-parietal connection contains temporal cortex and parietal cortex and their connectivity.
No. of Studies (Positive/Negative)	12(12/0)

Positive relationships between Temporo-parietal connection and MDD (count: 6)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
temporal cortex	Awata, 1998	patients and normal controls		(patients with major depressive disorder in late life) compa...... (patients with major depressive disorder in late life) compared with 13 age-matched controls, relative rCBF(regional cerebral blood flow) was significantly decreased bilaterally in the temporal cortex More...
temporal cortex	Bown, 2000	patients and normal controls		Increased levels of GRP78, GRP94, and calreticulin, a third ...... Increased levels of GRP78, GRP94, and calreticulin, a third member of the ER stress protein family, were found in temporal cortex of subjects with major depressive disorder who died by suicide compared with controls and subjects who died by other means. More...
temporoparietal cortex	Kimbrell, 2002	patients and normal controls		Compared with control subjects, the subgroup of patients wit...... Compared with control subjects, the subgroup of patients with Hamilton depression scores of 22 or greater demonstrated decreased absolute rCMRglu in the temporoparietal cortex (right > left) More...
temporal cortex	Nofzinger, 2005	patients and normal controls		Depressed patients showed smaller decreases than healthy sub...... Depressed patients showed smaller decreases than healthy subjects in relative metabolism in broad regions of the temporal cortex from waking to NREM sleep. More...
temporal cortex	Michopoulos, 2008	patients and normal controls		MDD patients showed neuropsychological deficits on tasks of ...... MDD patients showed neuropsychological deficits on tasks of executive function and memory, supporting the model of frontal-temporal dysfunction More...
right temporoparietal cortex	Moratti, 2008	patients and normal controls	F(1,28) = 7.2, P-value < .05	arousal modulation in controls was pronounced in the right t...... arousal modulation in controls was pronounced in the right temporoparietal cortex, weak arousal modulation characterized that brain region in patients with MDD (F(1,28) = 7.2, P < .05 for interaction group by quadraticcontrast). More...

Positive relationships between Temporo-parietal connection and other components at different levels (count: 10)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Related Components
Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
temporal cortex		ATP-citrate synthase(citrate synthase)	protein	Gardner, 2008	patients only		Voxel-based analysis showed significantly higher 99mTc-HMPAO...... Voxel-based analysis showed significantly higher 99mTc-HMPAO retention in the patients with low CS (citrate synthase) compared with the patients with normal CS in the posterior and inferior frontal cortex, the superior and posterior temporal cortex, the somato-sensory cortex, and the associative parietal cortex. More...
temporoparietal cortex		Arachidonic Acid(arachidonic acid)	molecule	Sublette, 2009	patients only		Docosahexaenoic acid (22:6n-3), arachidonic acid (20:4n-6), ...... Docosahexaenoic acid (22:6n-3), arachidonic acid (20:4n-6), and eicosapentaenoic acid (20:5n-3) were assessed as a percentage of total phospholipid PUFA (DHA%, AA%, and EPA%, respectively). DHA% and AA% correlated positively with rCMRglu (cerebral metabolic rates of glucose) in temporoparietal cortex. More...
temporoparietal cortex		Docosahexaenoic Acids(docosahexaenoic acid)	molecule	Sublette, 2009	patients only		Docosahexaenoic acid (22:6n-3), arachidonic acid (20:4n-6), ...... Docosahexaenoic acid (22:6n-3), arachidonic acid (20:4n-6), and eicosapentaenoic acid (20:5n-3) were assessed as a percentage of total phospholipid PUFA (DHA%, AA%, and EPA%, respectively). DHA% and AA% correlated positively with rCMRglu (cerebral metabolic rates of glucose) in temporoparietal cortex. More...
temporal cortex		Anhedonia(anhedonia)	symptoms	Dunn, 2002	patients only		In both unipolars and bipolars, the psychomotor-anhedonia sy...... In both unipolars and bipolars, the psychomotor-anhedonia symptom cluster correlated with lower absolute metabolism in temporal cortex, More...
temporal cortex		Increased agitation(psychomotor symptom)	symptoms	Dunn, 2002	patients only		In both unipolars and bipolars, the psychomotor-anhedonia sy...... In both unipolars and bipolars, the psychomotor-anhedonia symptom cluster correlated with lower absolute metabolism in temporal cortex, More...
temporal cortex		Suicide(suicide attempt)	symptoms	Dowlatshahi, 1999	patients and normal controls		We also detected a significant effect of suicide on temporal...... We also detected a significant effect of suicide on temporal cortex CREB levels in subjects that died as a result of suicide relative to those that did not, which was more evident in patients with major depressive disorder. More...
temporal cortex		Suicide(suicide attempt)	symptoms	Bown, 2000	patients and normal controls		Increased levels of GRP78, GRP94, and calreticulin, a third ...... Increased levels of GRP78, GRP94, and calreticulin, a third member of the ER stress protein family, were found in temporal cortex of subjects with major depressive disorder who died by suicide compared with controls and subjects who died by other means. More...
temporoparietal cortex		Depressed mood(depression)	symptoms	Kimbrell, 2002	patients and normal controls		Severity of depression negatively correlated with absolute r...... Severity of depression negatively correlated with absolute rCMRglu in temporoparietal cortex (right > left). More...
right temporoparietal junction		Psychotic symptoms(psychotic symptoms)	symptoms	Garrett, 2011	patients and normal controls		The psychotic major depression group was unique in showing g...... The psychotic major depression group was unique in showing greater activation than both other groups in the right temporoparietal junction, a cluster that also demonstrated connectivity with activation in the left prefrontal cortex. More...
temporo-parietal connection		Increased agitation(somatic anxiety)	symptoms	Lee, 2011	patients only		A higher symptom severity of somatic anxiety was associated ...... A higher symptom severity of somatic anxiety was associated with higher regional power over widespread cortical regions and lower strengths at bi-temporal, temporo-parietal and fronto-parietal connections. More...

Positive relationship network of Temporo-parietal connection in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between Temporo-parietal connection and MDD (count: 0)

Negative relationships between Temporo-parietal connection and other components at different levels (count: 0)

Temporo-parietal connection involved components (count: 2)

Name	Type
Temporal Lobe	brain morphology and function
Parietal Lobe	brain morphology and function