MK4MDD

Brain Morphology and Function Report

Basic Information
Name Subgenual cingulate
Brain Morphology "Brodmann area 25 (BA25) is an area in the cerebral cortex of the brain and delineated based on its cytoarchitectonic characteristics. It is also called the subgenual area, area subgenualis or subgenual cingulate. It is the 25th ""Brodmann area"" defined by Korbinian Brodmann (thus its name). BA25 is located in the cingulate region as a narrow band in the caudal portion of the subcallosal area adjacent to the paraterminal gyrus. The posterior parolfactory sulcus separates the paraterminal gyrus from BA25. Rostrally it is bound by the prefrontal area 11 of Brodmann."
Brain Function "This region is extremely rich in serotonin transporters and is considered as a governor for a vast network involving areas like hypothalamus and brain stem, which influences changes in appetite and sleep; the amygdala and insula, which affect the mood and anxiety; the hippocampus, which plays an important role in memory formation; and some parts of the frontal cortex responsible for self-esteem."
Picture Subgenual cingulate From Wiki. Magnify
No. of Studies (Positive/Negative) 9(9/0) Help

Positive relationships between Subgenual cingulate and MDD (count: 8)
Name in Literature Reference Research Type Statistical Result Relation Description Help
subgenual cingulate Greicius, 2007 patients and normal controls Resting-state subgenual cingulate and thalamic functional co...... Resting-state subgenual cingulate and thalamic functional connectivity with the default-mode network were significantly greater in the depressed subjects. More...
subgenual cortex Wagner, 2008 patients and normal controls Voxel-based morphometry (VBM) revealed grey matter decreases...... Voxel-based morphometry (VBM) revealed grey matter decreases in the subgenual cortex. More...
subgenual cingulate Matthews, 2008 patients and normal controls Although both groups activated the extended amygdala (EA) du...... Although both groups activated the extended amygdala (EA) during emotion processing, the MDD relative to the HC group showed more task-related co-activation of the subgenual cingulate More...
subgenual cingulate cortex Desseilles, 2009 patients and normal controls Analyses of fMRI data revealed that MDD patients show a hype...... Analyses of fMRI data revealed that MDD patients show a hyperactivity in subgenual cingulate/medial orbitofrontal cortex that was modulated by attentional load. More...
subgenual cingulate area Hsu, 2010 patients and normal controls Negative correlations were also found in the subgenual cingu...... Negative correlations were also found in the subgenual cingulate area 25, which are implicated in the pathophysiology of MDD. More...
subgenual cortex Terroni, 2011 high-risk people Major depressive episode was associated with larger lesions ...... Major depressive episode was associated with larger lesions in areas of the medial prefrontal cortex including the ventral (BA24) and dorsal anterior cingulate cortex (BA32) and subgenual cortex (BA25); and also the subiculum (BA28/36) and amygdala (BA34). More...
subgenual cingulate Aizenstein, 2011 patients and normal controls Greater subgenual cingulate activity was observed in the dep...... Greater subgenual cingulate activity was observed in the depressed patients relative to the nondepressed comparison subjects. More...
subgenual cingulate Hsu, 2012 patients and normal controls Among GG-homozygotes, BOLD signal in the subgenual cingulate...... Among GG-homozygotes, BOLD signal in the subgenual cingulate was greater in MDD participants (n = 9) compared with controls (n = 33). More...

Positive relationships between Subgenual cingulate and other components at different levels (count: 4) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Subgenual cingulate in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Subgenual cingulate and MDD (count: 0)
Negative relationships between Subgenual cingulate and other components at different levels (count: 0) Help