Environment Report

Name	Social defeat
Description	Social defeat refers to losing a confrontation among conspecific animals, or any kind of hostile dispute among humans, in either a dyadic or in a group-individual context, generating very significant consequences in terms of control over resources, access to mates and social positions. It has been proposed that animal models of social conflict may be useful for studying a number of psychiatric disorders, including major depression, generalized anxiety, post-traumatic stress disorder, drug abuse, aggressive psychopathologies, eating disorders and even schizophrenia (Bjorkqvist, 2001; Selten & Cantor-Graae, 2005; Rohde, 2001).
No. of Studies (Positive/Negative)	4(4/0)

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
social defeat		FGF2(FGF2)	gene	Turner, 2008	animal model		Molecular components of the FGF system were significantly do...... Molecular components of the FGF system were significantly downregulated following social defeat. Specifically, FGF2 and FGFR1 mRNA expression was decreased in various subfields of the hippocampus More...
social defeat		FGFR1(FGFR1)	gene	Turner, 2008	animal model		Molecular components of the FGF system were significantly do...... Molecular components of the FGF system were significantly downregulated following social defeat. Specifically, FGF2 and FGFR1 mRNA expression was decreased in various subfields of the hippocampus More...
chronic social defeat (CSD)		HTR1A(5-HT1A)	gene	Kieran, 2010	animal model		5-HT1A mRNA levels were significantly downregulated in the p...... 5-HT1A mRNA levels were significantly downregulated in the prefrontal cortex (PFC) in defeated animals More...
social defeat		Neuronal migration protein doublecortin(DCX)	protein	Van Bokhoven, 2011	animal model		Using this social defeat paradigm, the total DCX(+) cell num...... Using this social defeat paradigm, the total DCX(+) cell number was significantly reduced. More...
social defeat		Hippocampus(hippocampus)	brain morphology and function	Turner, 2008	animal model		Molecular components of the FGF system were significantly do...... Molecular components of the FGF system were significantly downregulated following social defeat. Specifically, FGF2 and FGFR1 mRNA expression was decreased in various subfields of the hippocampus More...
chronic social defeat (CSD)		Prefrontal cortex(prefrontal cortex)	brain morphology and function	Kieran, 2010	animal model		5-HT1A mRNA levels were significantly downregulated in the p...... 5-HT1A mRNA levels were significantly downregulated in the prefrontal cortex (PFC) in defeated animals More...
social defeat		anhedonic-like behavior from animal model(anhedonic-like behavior)	cognition and behavior	Hollis F, 2011	animal model		Rats are known to exhibit either high locomotor activity and...... Rats are known to exhibit either high locomotor activity and sustained exploration consumed more sucrose solution than low activity with minimal exploration rats, but reduced consumption after exposure to defeat More...

---

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web