MK4MDD

Brain Morphology and Function Report

Basic Information
Name Posterior cingulate cortex
Brain Morphology "The posterior cingulate cortex is the backmost part of the cingulate cortex, lying behind the anterior cingulate cortex. This is the upper part of the ""limbic lobe"". The cingulate cortex is made up of an area around the midline of the brain.Surrounding areas include the retrosplenial cortex and the precuneus. Cytoarchitectonically the posterior cingulate cortex is associated with Brodmann areas 23 and 31."
Brain Function "The posterior cingulate forms a central node in the ""default mode"" network of the brain. Along with the precuneus, it has been implicated as a neural substrate for human awareness in numerous studies of both the anesthesized and vegetative (coma) state. Imaging studies indicate a prominent role for the posterior cingulate cortex in pain and episodic memory retrieval. The posterior cingulate may also be involved in the capacity to understand what other people believe."
Picture Posterior cingulate cortex From Wiki. Magnify
No. of Studies (Positive/Negative) 17(17/0) Help

Positive relationships between Posterior cingulate cortex and MDD (count: 15)
Name in Literature Reference Research Type Statistical Result Relation Description Help
posterior cingulate Alexopoulos, 2009 patients only Depressed elders (N=27) had lower FA (fractional anisotropy)...... Depressed elders (N=27) had lower FA (fractional anisotropy) than controls (N=27) in several frontolimbic areas, including the posterior cingulate, More...
posterior cingulate Pizzagalli, 2002 patients and normal controls Depressed subjects showed posterior cingulate hypoactivity. Depressed subjects showed posterior cingulate hypoactivity.
posterior cingulate cortex Drevets, 2002 patients only At baseline, the mean glucose metabolism was increased in th...... At baseline, the mean glucose metabolism was increased in the posterior cingulate cortex in the unmedicated depressives relative to controls. More...
posterior cingulate cortices Neumeister, 2004 patients and normal controls Compared with sham depletion, TD (tryptophan depletion) was ...... Compared with sham depletion, TD (tryptophan depletion) was associated with an increase in regional cerebral glucose utilization in the posterior cingulate cortices in patients with remitted MDD but not in controls. More...
posterior cingulate Dunn, 2005 patients and normal controls Unipolars had significantly fewer positive regional correlat...... Unipolars had significantly fewer positive regional correlation coefficients than healthy controls and bipolars. These were significantly different from controls in orbital cortex, anterior cingulate, posterior cingulate, and posterior temporal cortex More...
posterior cingulate volumes Caetano, 2006 patients and normal controls The unipolar patients had significantly smaller anterior and...... The unipolar patients had significantly smaller anterior and posterior cingulate volumes bilaterally compared with healthy control subjects. More...
posterior cingulate cortex Grimm, 2009 patients and normal controls MDD patients showed significantly reduced NBRs (negative blo...... MDD patients showed significantly reduced NBRs (negative blood oxygenation level-dependent responses) in several regions of the default-mode network such as the pregenual anterior cingulate cortex, the ventromedial prefrontal cortex, and the posterior cingulate cortex. More...
bilateral mid-posterior cingulate Zhang, 2009 patients and normal controls Compared with healthy participants, patients with major depr...... Compared with healthy participants, patients with major depressive disorder showed significantly decreased local gyrification index in the bilateral mid-posterior cingulate, More...
posterior cingulate cortex van Wingen, 2010 patients and normal controls The amygdala and posterior cingulate cortex were involved in...... The amygdala and posterior cingulate cortex were involved in memory retrieval of happy faces in depressed patients only. More...
posterior cingulate cortex Bluhm, 2009 patients and normal controls Direct comparison showed significantly reduced correlation b...... Direct comparison showed significantly reduced correlation between the P/PCC(precuneus/posterior cingulate cortex) and the bilateral caudate in depression compared with controls and no areas of increased connectivity in the depressed group. More...
posterior cingulate Cooney, 2010 patients and normal controls Neural activity during rumination versus abstract distractio...... Neural activity during rumination versus abstract distraction was greater for depressed than for control participants in the amygdala, rostral anterior cingulate/medial prefrontal cortex, dorsolateral prefrontal cortex, posterior cingulate, and parahippocampus. More...
posterior cingulate Monkul, 2012 patients and normal controls Depressed patients showed increased blood flow in left and r...... Depressed patients showed increased blood flow in left and right posterior cingulate (Brodmann areas 23, 29, 30) compared with healthy volunteers. More...
posterior cingulate cortex Jarnum, 2011 patients and normal controls Major findings were a significantly thinner posterior cingul...... Major findings were a significantly thinner posterior cingulate cortex in non-remitters than in remitters More...
posterior cingulate Kumar, 2011 patients and normal controls When compared with controls, [(18)F]FDDNP binding was signif...... When compared with controls, [(18)F]FDDNP binding was significantly higher overall and in the posterior cingulate in the MDD group. More...
posterior cingulate cortex Zhu, 2012 patients and normal controls We observed decreased functional connectivity in the posteri...... We observed decreased functional connectivity in the posterior medial cortex regions (especially the posterior cingulate cortex/precuneus) in MDD patients compared with control subjects. More...

Positive relationships between Posterior cingulate cortex and other components at different levels (count: 7) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of Posterior cingulate cortex in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Posterior cingulate cortex and MDD (count: 0)
Negative relationships between Posterior cingulate cortex and other components at different levels (count: 0) Help