Brain Morphology and Function Report

Name	Nucleus accumbens
Brain Morphology	The nucleus accumbens (NAcc) is a collection of neurons within the striatum.
Brain Function	It is thought to play an important role in reward, pleasure, laughter, addiction, aggression, fear, and the placebo effect.
Picture	From Wiki.
No. of Studies (Positive/Negative)	8(8/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
nucleus accumbens	Pizzagalli, 2009	patients and normal controls		Relative to comparison subjects, participants with major dep...... Relative to comparison subjects, participants with major depression showed significantly weaker responses to gains in the left nucleus accumbens. More...
nucleus accumbens (NAcc)	Heller AS, 2009	patients and normal controls		While up-regulating positive affect, depressed individuals f...... While up-regulating positive affect, depressed individuals failed to sustain nucleus accumbens activity over time compared with controls. More...
nucleus accumbens	Monk, 2008	high-risk people and normal controls		When attention was unconstrained, high-risk subjects showed ...... When attention was unconstrained, high-risk subjects showed greater nucleus accumbens activation to fearful faces and lower nucleus accumbens activation to happy faces. More...
nucleus accumbens	Hsu, 2010	patients and normal controls		Negative correlations were also found in the nucleus accumbe...... Negative correlations were also found in the nucleus accumbens, which are implicated in the pathophysiology of MDD. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
nucleus accumbens (NAcc)		Reward system(brain reward system)	brain morphology and function	Schlaepfer, 2008	patients only		Dysfunctions of the reward system--in which the nucleus accu...... Dysfunctions of the reward system--in which the nucleus accumbens is a key structure--are implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. More...
nucleus accumbens (NAcc)		anhedonic-like behavior from animal model(anhedonic-like behavior)	cognition and behavior	Muschamp JW, 2011	animal model		Elevated CREB within the nucleus accumbens shell produced in...... Elevated CREB within the nucleus accumbens shell produced increases in intracranial self-stimulation thresholds, a depressive-like sign reflecting anhedonia More...
nucleus accumbens (NAcc)		Emotion(conditioned fear)	cognition and behavior	Muschamp JW, 2011	animal model		Elevation of CREB within the nucleus accumbens shell impaire...... Elevation of CREB within the nucleus accumbens shell impaired extinction of conditioned fear More...
nucleus accumbens (NAcc)		Anhedonia(anhedonia)	symptoms	Wacker, 2009	normal people		Anhedonia was correlated with reduced nucleus accumbens (NAc...... Anhedonia was correlated with reduced nucleus accumbens (NAcc) responses to rewards (gains in a monetary incentive delay task). More...
nucleus accumbens		Anhedonia(anhedonia)	symptoms	Gradin, 2010	patients and normal controls		The extent of signal reduction in nucleus accumbens correlat...... The extent of signal reduction in nucleus accumbens correlating with increased anhedonia severity in depression. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web