Protein Report

Protein Name	Mu-type opioid receptor
UniPortKB	P35372
No. of Studies (Positive/Negative)	1 (1/0)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
mu-opioid receptor	Kennedy, 2006	patients and normal controls		The sustained sadness condition was associated with a statis...... The sustained sadness condition was associated with a statistically significant decrease in mu-opioid receptor BP in the left inferior temporal cortex of patients with MDD. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
mu-opioid receptor		Amygdala(amygdala)	brain morphology and function	Kennedy, 2006	patients and normal controls		Larger reductions in mu-opioid system BP during sadness were...... Larger reductions in mu-opioid system BP during sadness were obtained in patients with MDD in the anterior insular cortex, anterior and posterior thalamus, ventral basal ganglia, amygdala, and periamygdalar cortex. More...
mu-opioid receptor		Anterior cingulate cortex(anterior cingulate)	brain morphology and function	Kennedy, 2006	patients and normal controls		In this region(anterior cingulate), a significant decrease i...... In this region(anterior cingulate), a significant decrease in mu-opioid receptor BP during sadness was observed in patients with MDD who did not respond to antidepressant treatment. More...
mu-opioid receptor		Insular cortex(anterior insular cortex)	brain morphology and function	Kennedy, 2006	patients and normal controls		Larger reductions in mu-opioid system BP during sadness were...... Larger reductions in mu-opioid system BP during sadness were obtained in patients with MDD in the anterior insular cortex, anterior and posterior thalamus, ventral basal ganglia, amygdala, and periamygdalar cortex. More...
mu-opioid receptor		left inferior temporal gyrus(left inferior temporal cortex)	brain morphology and function	Kennedy, 2006	patients and normal controls		The sustained sadness condition was associated with a statis...... The sustained sadness condition was associated with a statistically significant decrease in mu-opioid receptor BP in the left inferior temporal cortex of patients with MDD. More...
mu-opioid receptor		Periamygdalar cortex(periamygdalar cortex)	brain morphology and function	Kennedy, 2006	patients and normal controls		Larger reductions in mu-opioid system BP during sadness were...... Larger reductions in mu-opioid system BP during sadness were obtained in patients with MDD in the anterior insular cortex, anterior and posterior thalamus, ventral basal ganglia, amygdala, and periamygdalar cortex. More...
mu-opioid receptor		Thalamus(thalamus)	brain morphology and function	Kennedy, 2006	patients and normal controls		Comparisons between patients with MDD and controls showed si...... Comparisons between patients with MDD and controls showed significantly lower neutral-state mu-opioid receptor BP in patients with MDD in the posterior thalamus, correlating with corticotropin and cortisol plasma levels. Larger reductions in mu-opioid system BP during sadness were obtained in patients with MDD in the anterior insular cortex, anterior and posterior thalamus, ventral basal ganglia, amygdala, and periamygdalar cortex. More...
mu-opioid receptor		ventral basal ganglia(ventral basal ganglia)	brain morphology and function	Kennedy, 2006	patients and normal controls		Larger reductions in mu-opioid system BP during sadness were...... Larger reductions in mu-opioid system BP during sadness were obtained in patients with MDD in the anterior insular cortex, anterior and posterior thalamus, ventral basal ganglia, amygdala, and periamygdalar cortex. More...

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1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
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Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
OPRM1	opioid receptor, mu 1	Literature-origin; Protein mapped	1 (1/0)