Brain Morphology and Function Report

Name	Left amygdala
Brain Morphology	Please reference to the description for Amygdala
No. of Studies (Positive/Negative)	15(15/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
left amygdala	Sheline, 2001	patients and normal controls		Depressed patients have left amygdala hyperarousal, even whe...... Depressed patients have left amygdala hyperarousal, even when processing stimuli outside conscious awareness. Increased amygdala activation normalizes with antidepressant treatment. More...
left amygdala	Fu, 2004	patients and normal controls		Over time, depressed subjects showed reduced capacity for ac...... Over time, depressed subjects showed reduced capacity for activation in the left amygdala. More...
left amygdala	Drevets, 2002	patients only		At baseline, the mean glucose metabolism was increased in th...... At baseline, the mean glucose metabolism was increased in the left amygdala in the unmedicated depressives relative to controls. More...
left amygdala	Nofzinger, 2005	patients and normal controls		Depressed patients showed larger decreases than healthy subj...... Depressed patients showed larger decreases than healthy subjects in relative metabolism in the left amygdala More...
left amygdala	Roberson-Nay, 2006	patients and normal controls		MDD patients exhibited greater left amygdala activation rela...... MDD patients exhibited greater left amygdala activation relative to healthy and anxious youth. More...
left amygdala	Frodl, 2008	patients and normal controls		Compared with controls, patients showed significantly more d...... Compared with controls, patients showed significantly more decline in gray matter density of the left amygdala More...
left amygdala	Lorenzetti, 2010	patients and normal controls		We found that left amygdala volumes of rMDD subjects were si...... We found that left amygdala volumes of rMDD subjects were significantly larger as compared to healthy controls, and tended to be larger when compared to cMDD subjects. More...
left amygdala	Yang, 2010	patients and normal controls		significantly greater left amygdala activation in depressed ...... significantly greater left amygdala activation in depressed adolescents compared to controls More...
left amygdala	Salvadore, 2010	patients only	r=-0.73, P-value = 0.0021, FDR <0.05	Pretreatment functional connectivity between the pgACC and t...... Pretreatment functional connectivity between the pgACC and the left amygdala was negatively correlated with antidepressant symptom change (r=-0.73, p=0.0021, FDR <0.05).These data implicate the pgACC and its putative interaction with the amygdala in predicting antidepressant response to ketamine in a working memory task context. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
left amygdala		SLC6A4(serotonin transporter gene (5-HTTLPR))	gene	Frodl, 2008	patients and normal controls		We found that healthy controls have a strong association bet...... We found that healthy controls have a strong association between the 5-HTTLPR and GM (gray matter) volumes of the left amygdala , whereas there is no such association in patients with major depression. Healthy subjects carrying the S- or L(G)-allele have smaller GM volumes than those with the L(A)-allele More...
left amygdala		Tryptophan(tryptophan)	molecule	Morris, 1999	patients only		Task-specific responses in left amygdala and left anterior c...... Task-specific responses in left amygdala and left anterior cingulate were attenuated by tryptophan depletion. More...
left amygdala		pregenual anterior cingulate cortex(pregenual anterior cingulate cortex (pgACC))	brain morphology and function	Salvadore, 2010	patients only	r=-0.73, P-value = 0.0021, FDR <0.05	Pretreatment functional connectivity between the pgACC and t...... Pretreatment functional connectivity between the pgACC and the left amygdala was negatively correlated with antidepressant symptom change (r=-0.73, p=0.0021, FDR <0.05).These data implicate the pgACC and its putative interaction with the amygdala in predicting antidepressant response to ketamine in a working memory task context. More...
left amygdala		Emotional memory(impaired emotional memory)	cognition and behavior	Weniger, 2006	patients and normal controls		Correlation analyses revealed that larger left amygdala volu...... Correlation analyses revealed that larger left amygdala volumes were significantly related to worse memory performance and to higher anxiety scores of depressive subjects. More...
left amygdala		Irritability(anger attacks)	symptoms	Dougherty, 2004	patients and normal controls		Also, in controls, an inverse relationship was demonstrated ...... Also, in controls, an inverse relationship was demonstrated between regional cerebral blood flow changes during anger induction in the left ventromedial prefrontal cortex and left amygdala, whereas in patients with MDD + A there was a positive correlation between these brain regions during anger induction. More...
left amygdala		Depressed mood(depressive mood)	symptoms	Perico, 2005	patients and normal controls	P-value < 0.001, uncorrected for multiple comparisons	Severity of depressive mood was inversely correlated with rC...... Severity of depressive mood was inversely correlated with rCBF in the left amygdala, lentiform nucleus, and parahippocampal gyrus, and directly correlated with rCBF in the right postero-lateral parietal cortex (p < 0.001, uncorrected for multiple comparisons). More...
left amygdala		Increased agitation(anxiety)	symptoms	Weniger, 2006	patients and normal controls		Correlation analyses revealed that larger left amygdala volu...... Correlation analyses revealed that larger left amygdala volumes were significantly related to worse memory performance and to higher anxiety scores of depressive subjects. More...
left amygdala		Depressed mood(depression)	symptoms	Lee, 2007	patients and normal controls		Within the MDD group, the severity of depression correlated ...... Within the MDD group, the severity of depression correlated with the activity of the left amygdala to negative pictures. More...

---

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web