Pathway Report

Name	glutamate decarboxylase activity
GO Link	ID: GO:0004351 Name: glutamate decarboxylase activity Type: molecular function
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
glutamic acid decarboxylase (GAD)	Karolewicz, 2010	patients and normal controls		The overall amount of GAD-67 was significantly reduced (-34%...... The overall amount of GAD-67 was significantly reduced (-34%) in depressed subjects compared to matched controls. The overall amounts of GAD-65 were similar in depressed subjects compared to matched controls, regardless of antidepressant medication. More...

---

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
GAD1	glutamate decarboxylase 1 (brain, 67kDa)	Literature-origin; Protein mapped	2(1/1)
GLUL	glutamate-ammonia ligase	Literature-origin; Protein mapped	3(3/0)
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	Literature-origin; Protein mapped	2(2/0)