Pathway Report

Name	ECM-receptor interaction
KEGG Link	ID: hsa04512 Name: ecm receptor_interaction Brief Description: ECM-receptor interaction Full Description: The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
No. of Studies (Positive/Negative)	1 (1/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
ECM-receptor interaction	Kao CF, 2012	patients and normal controls		We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
LAMC1	laminin, gamma 1 (formerly LAMB2)	Protein mapped	0(0/0)
VTN	vitronectin	Protein mapped	0(0/0)
COMP	cartilage oligomeric matrix protein	Literature-origin	1(1/0)
SV2B	synaptic vesicle glycoprotein 2B	Literature-origin	2(2/0)
ITGB5	integrin, beta 5	Literature-origin	1(1/0)
CD44	CD44 molecule (Indian blood group)	Protein mapped	0(0/0)
COL6A1	collagen, type VI, alpha 1	Protein mapped	0(0/0)
SV2A	synaptic vesicle glycoprotein 2A	Protein mapped	0(0/0)
SDC4	syndecan 4	Literature-origin	1(1/0)