MK4MDD

Pathway Report

Basic Information
Name ECM-receptor interaction
KEGG Link ID: hsa04512
Name: ecm receptor_interaction
Brief Description: ECM-receptor interaction
Full Description: The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
No. of Studies (Positive/Negative) 1 (1/0) Help

Positive relationship between ECM-receptor interaction and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
ECM-receptor interaction Kao CF, 2012 patients and normal controls We found 17 significantly enriched pathways for depression We found 17 significantly enriched pathways for depression

Positive relationships between ECM-receptor interaction and other components at different levels (count: 0) Help
Positive relationship network of ECM-receptor interaction in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between ECM-receptor interaction and MDD (count: 0)
Negative relationships between ECM-receptor interaction and other components at different levels (count: 0) Help
Pathway ECM-receptor interaction related genes in MK4MDD (count: 11)