Protein Report

Basic Information

Protein Name	5-hydroxytryptamine receptor 2A
UniPortKB	P28223
No. of Studies (Positive/Negative)	8 (7/1)
Type	Literature-origin

Positive relationship between 5-hydroxytryptamine receptor 2A and MDD (count: 6)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
5-HT2 receptor (serotonin-2 receptor)	Biver, 1997	patients and normal controls		In depressed patients, [18F]altanserin uptake was significan...... In depressed patients, [18F]altanserin uptake was significantly reduced in a region of the right hemisphere including the posterolateral orbitofrontal cortex and the anterior insular cortex. More...
5-HT2 receptor (serotonin-2 receptor)	Yatham, 1999	patients only		Depressed patients showed a significant decrease in 5-HT2 re...... Depressed patients showed a significant decrease in 5-HT2 receptor binding as measured by setoperone binding in frontal, temporal, parietal, and occipital cortical regions following desipramine treatment. More...
5-HT(2A) receptors	Messa, 2003	patients and normal controls		The reduction of [(18)F]FESP BI in cortical areas of DN depr...... The reduction of [(18)F]FESP BI in cortical areas of DN depressed, but not of euthymic DT patients suggests an association between the occurrence of depressive symptoms and impairment of cortical 5-HT(2A) receptors. More...
5-HT(2A) receptor	Mintun, 2004	patients and normal controls	P-value=0.004	5-HT(2A) receptor binding in the hippocampus was reduced by ...... 5-HT(2A) receptor binding in the hippocampus was reduced by 29% in depressed subjects (p =.004). More...
5-HT(2A) receptor	Sheline, 2004	patients and normal controls	P-value=0.05	Depressed subjects had less hippocampal 5-HT(2A) receptor bi...... Depressed subjects had less hippocampal 5-HT(2A) receptor binding than controls (p = 0.05). More...
5-HT(2A) receptor	Shelton, 2009	patients and normal controls		The depressed samples showed significantly increased 5-HT(2A...... The depressed samples showed significantly increased 5-HT(2A) receptor abundance relative to controls More...

Positive relationships between 5-hydroxytryptamine receptor 2A and other components at different levels (count: 7)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
5-HT(2A) receptor		cAMP-dependent protein kinase catalytic subunit alpha(PKA)	protein	Shelton, 2009	patients and normal controls	5-HT(2A) receptor availability was significantly inversely c...... 5-HT(2A) receptor availability was significantly inversely correlated with PKC activity in controls, but with PKA activity in the depressed sample More...
5-HT(2A) receptor		protein kinase C activity(PKC)	pathway	Shelton, 2009	patients and normal controls	5-HT(2A) receptor availability was significantly inversely c...... 5-HT(2A) receptor availability was significantly inversely correlated with PKC activity in controls, but with PKA activity in the depressed sample More...
5-HT2 receptor (serotonin-2 receptor)		Insular cortex(anterior insular cortex)	brain morphology and function	Biver, 1997	patients and normal controls	In depressed patients, [18F]altanserin uptake was significan...... In depressed patients, [18F]altanserin uptake was significantly reduced in a region of the right hemisphere including the posterolateral orbitofrontal cortex and the anterior insular cortex. More...
5-HT2 receptor (serotonin-2 receptor)		posterolateral orbitofrontal cortex(posterolateral orbitofrontal cortex)	brain morphology and function	Biver, 1997	patients and normal controls	In depressed patients, [18F]altanserin uptake was significan...... In depressed patients, [18F]altanserin uptake was significantly reduced in a region of the right hemisphere including the posterolateral orbitofrontal cortex and the anterior insular cortex. More...
5-HT2 receptor (serotonin-2 receptor)		Fronto-parietal connection(frontal cortex)	brain morphology and function	Yatham, 1999	patients only	The decrease in 5-HT2 receptor binding was observed bilatera...... The decrease in 5-HT2 receptor binding was observed bilaterally and was particularly prominent in frontal cortex. More...
5HT(2A)		Suicide(suicide attempt)	symptoms	Roggenbach, 2007	patients and normal controls	Mean K(D) for the platelet 5HT(2A) receptor and MAO-B activi...... Mean K(D) for the platelet 5HT(2A) receptor and MAO-B activity were significantly lower in suicidal patients as compared to nonsuicidal depressed patients and healthy controls More...
brain 5-HT(2) receptor		Depressed mood(depressive symptoms)	symptoms	Yatham, 2010	patients only	There was a trend for correlation between reduction in brain...... There was a trend for correlation between reduction in brain 5-HT(2) receptors in right parahippocampal gyrus, right lingual gyrus and right medial frontal gyrus, and improvement in depressive symptoms. More...

Positive relationship network of 5-hydroxytryptamine receptor 2A in MK4MDD

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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between 5-hydroxytryptamine receptor 2A and MDD (count: 0)

Negative relationships between 5-hydroxytryptamine receptor 2A and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
5-HT2 receptor		Depressed mood(depressed mood)	symptoms	Biver, 1997	patients and normal controls		No correlation was found between the [18F]altanserin uptake...... No correlation was found between the [18F]altanserin uptake and the Hamilton rating scale score. More...

Related Gene Info

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	Literature-origin; SNP mapped; Protein mapped	9 (7/2)