MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Lee, 2009 PubMed
Full Info	Lee, B.T., Lee, H.Y., Lee, B.C., Pae, C.U., Yoon, B.J., Ryu, S.G., Choi, I.G., Lee, M.S. and Ham, B.J. (2009) Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder. Genes Brain Behav, 8, 512-518.

Study

Hypothesis or Background	Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression.
Sample Information	26 right-handed female subjects with major depressive disorder (MDD)
Method Detail	Using 1.5-Tesla functional magnetic resonance imaging, we investigated the possible relationship between TPH1 A218C polymorphism and amygdala response to negative facial stimuli in 26 right-handed female subjects with major depressive disorder (MDD). Genotyping was performed with the polymerase chain reaction
Method Keywords	functional magnetic resonance imaging (fMRI); Q-PCR
Result	We found a significant association between A allele of the TPH1 A218C polymorphism and neural activations in response to negative facial stimuli. Subjects with the A allele of the TPH1 A218C polymorphism showed greater brain activity in the bilateral amygdala under the sad vs. the neutral condition compared with subjects homozygous for the C allele.
Conclusions	Our results suggest that the A218C polymorphism of the TPH1 gene serves as a modulator of amygdala activity in patients with MDD.

Relationships reported by Lee, 2009