Study Report
Reference
| Citation | Numata, 2009 PubMed |
| Full Info | Numata, S., Iga, J., Nakataki, M., Tayoshi, S., Taniguchi, K., Sumitani, S., Tomotake, M., Tanahashi, T., Itakura, M., Kamegaya, Y. et al. (2009) Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. Am J Med Genet B Neuropsychiatr Genet, 150B, 527-534.
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Study
| Hypothesis or Background |
The phosphodiesterase 4B (PDE4B) interacts with disrupted-in-schizophrenia 1 (DISC1), which is a known genetic risk factor for schizophrenia, bipolar disorder and major depressive disorder (MDD). PDE4B is also important in the regulation of cAMP signaling, a second messenger implicated in learning, memory, and mood.
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| Sample Information | MDD and control subjects (n = 33, each); (first set; case = 174, controls = 348; second set; case = 481, controls = 812) |
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| Method Detail | In this study, we determined mRNA expression levels of the PDE4B gene in the peripheral blood leukocytes of patients with MDD and control subjects (n = 33, each). Next we performed two-stage case-controlled association analyses (first set; case = 174, controls = 348; second set; case = 481, controls = 812) in the Japanese population to determine if the PDE4B gene is implicated in MDD. |
| Method Keywords | blood analysis; genotyping |
| Result | In the leukocytes, a significantly higher expression of the PDE4B mRNA was observed in the drug-naive MDD patients compared with control subjects (P < 0.0001) and the expression of the MDD patients significantly decreased after antidepressant treatment (P = 0.030). In the association analysis, we observed significant allelic associations of four SNPs (the most significant, rs472952; P = 0.002) and a significant haplotypic association (permutation P = 0.019) between the PDE4B gene and MDD in the first-set samples. However, we could not confirm these significant associations in the following independent second-set of samples. |
| Conclusions | Our results suggest that the PDE4B gene itself does not link to MDD but the elevated mRNA levels of PDE4B might be implicated in the pathophysiology of MDD. |
Relationships reported by
Numata, 2009
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
|
syndrome |
PDE4B (PDE4B) |
gene |
P-value < 0.0001 |
In the leukocytes, a significantly higher expression of the PDE4B mRNA was observed in the drug-naive MDD patients compared with control subjects (P < 0.0001); In the association analysis, we observed significant allelic associations of four SNPs (the most significant, rs472952; P = 0.002) and a significant haplotypic association (permutation P = 0.019) between the PDE4B gene and MDD in the first-set samples. |
Positive
|
|
MDD
|
syndrome |
rs472952 (rs472952) |
SNP |
P-value = 0.002 |
In the association analysis, we observed significant allelic associations of four SNPs (the most significant, rs472952; P = 0.002) |
Positive
|
|
MDD
|
syndrome |
Leukocytes (leukocytes) |
cell |
P-value-value<0.0001 |
In the leukocytes, a significantly higher expression of the PDE4B mRNA was observed in the drug-naive MDD patients compared with control subjects (P < 0.0001) and the expression of the MDD patients significantly decreased after antidepressant treatment (P = 0.030). I |
Positive
|
