Study Report
Reference
| Citation | Hejjas, 2009 PubMed |
| Full Info | Hejjas, K., Szekely, A., Domotor, E., Halmai, Z., Balogh, G., Schilling, B., Sarosi, A., Faludi, G., Sasvari-Szekely, M. and Nemoda, Z. (2009) Association between depression and the Gln460Arg polymorphism of P2RX7 gene: a dimensional approach. Am J Med Genet B Neuropsychiatr Genet, 150B, 295-299
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Study
| Hypothesis or Background |
The P2RX7 gene (coding for P2X7 purinergic receptor) has been suggested as a novel candidate gene for major depressive disorder (MDD) and bipolar disorder (BPD). The proposed risk allele (G-allele) of the rs2230912 polymorphism results in an amino acid change at the 460th position, marking this genetic variation a possibly functional one.
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| Sample Information | 171 patients diagnosed with MDD or BPD and 178 controls |
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| Method Detail | Here we present a case-control analysis of 171 patients diagnosed with MDD or BPD and 178 controls, as well as a dimensional approach using the Hospital Anxiety and Depression Scale (HADS) for studying the Gln460Arg polymorphism of the P2RX7 gene as a genetic risk factor in depression. |
| Method Keywords | genotyping |
| Result | While case-control analysis did not show significant difference between the groups, a significant association was found between the P2RX7 polymorphism and the HADS scales in the clinical group (MANOVA P = 0.001). Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups (ANOVA for HADS-anxiety: P = 0.01, HADS-depression: P < 0.001). A significant interaction of clinical status and the P2RX7 polymorphism was also found for the depression scale (MANOVA P = 0.025, subsequent ANOVA for anxiety: P = 0.252; depression: P = 0.002). Whereas patients with G-allele-present genotypes showed more elevated depression scores, level of depression in the control group was not affected by the P2RX7 genotype. |
| Conclusions | In conclusion, case-control analysis did not reveal significant results, but using a symptom severity scale we could support the association between depressive disorder and the G-allele of the Gln460Arg polymorphism in the P2RX7 gene. |
Relationships reported by
Hejjas, 2009
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
Increased agitation (anxiety)
|
symptoms |
P2RX7 (P2RX7) |
gene |
P-value = 0.01 |
Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups (ANOVA for HADS-anxiety: P = 0.01, HADS-depression: P < 0.001) |
Positive
|
|
Depressed mood (depression)
|
symptoms |
P2RX7 (P2RX7) |
gene |
P-value<0.01 |
Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups (ANOVA for HADS-anxiety: P = 0.01, HADS-depression: P < 0.001) |
Positive
|
|
Increased agitation (anxiety)
|
symptoms |
rs2230912 (rs2230912) |
SNP |
P-value = 0.01 |
Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups (ANOVA for HADS-anxiety: P = 0.01, HADS-depression: P < 0.001) |
Positive
|
|
Depressed mood (depression)
|
symptoms |
rs2230912 (rs2230912) |
SNP |
P-value < 0.001 |
Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups (ANOVA for HADS-anxiety: P = 0.01, HADS-depression: P < 0.001) |
Positive
|
