Study Report
Reference
Citation | Dannlowski, 2007 PubMed |
Full Info | Dannlowski, U., Ohrmann, P., Bauer, J., Kugel, H., Baune, B.T., Hohoff, C., Kersting, A., Arolt, V., Heindel, W., Deckert, J. et al. (2007) Serotonergic genes modulate amygdala activity in major depression. Genes Brain Behav, 6, 672-676.
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Study
Hypothesis or Background |
Serotonergic genes have been implicated in the pathogenesis of depression probably via their influence on neural activity during emotion processing.
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Sample Information | 27 medicated patients with major depression |
Method Detail | This study used an imaging genomics approach to investigate amygdala activity in major depression as a function of common functional polymorphisms in the serotonin transporter gene (5-HTTLPR) and the serotonin receptor 1A gene (5-HT(1A)-1019C/G). In 27 medicated patients with major depression, amygdala responses to happy, sad and angry faces were assessed using functional magnetic resonance imaging at 3 Tesla. Patients were genotyped for the 5-HT(1A)-1019C/G and the 5-HTTLPR polymorphism, including the newly described 5-HTT-rs25531 single nucleotide polymorphism. |
Method Keywords | functional magnetic resonance imaging (fMRI); genotyping |
Result | Risk allele carriers for either gene showed significantly increased bilateral amygdala activation in response to emotional stimuli, implicating an additive effect of both genotypes. |
Conclusions | Our data suggest that the genetic susceptibility for major depression might be transported via dysfunctional neural activity in brain regions critical for emotion processing. |
Relationships reported by
Dannlowski, 2007
Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
Amygdala (amygdala)
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brain morphology and function |
SLC6A4 (5-HTTLPR) |
gene |
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Risk allele carriers for either gene showed significantly increased bilateral amygdala activation in response to emotional stimuli, implicating an additive effect of both genotypes. |
Positive
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Amygdala (amygdala)
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brain morphology and function |
HTR1A (5-HT(1A)) |
gene |
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Risk allele carriers for either gene showed significantly increased bilateral amygdala activation in response to emotional stimuli, implicating an additive effect of both genotypes. |
Positive
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