Study Report
Reference
Citation | Lopez de Lara, 2007 PubMed |
Full Info | Lopez de Lara, C., Brezo, J., Rouleau, G., Lesage, A., Dumont, M., Alda, M., Benkelfat, C. and Turecki, G. (2007) Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression. Biol Psychiatry, 62, 72-80.
|
Study
Hypothesis or Background |
Suicide and depressive disorders are strongly associated, yet not all depressed patients commit suicide. Genetic factors may partly explain this difference. We investigated whether variation at the tryptophan hydroxylase-2 (TPH2) gene and its 5' upstream region may predispose to suicide in major depressive disorder (MDD) and whether this predisposition is mediated by impulsive-aggressive behaviors (IABs).
|
Sample Information | 259 depressed subjects, 114 of which committed suicide while depressed |
Method Detail | We genotyped 14 single nucleotide polymorphisms (SNPs) in 259 depressed subjects, 114 of which committed suicide while depressed. Phenotypic assessments were carried out by means of proxy-based interviews. Single-marker and haplotype association analyses were conducted. Differences in behavioral and personality traits according to genotypic variation were investigated, as well as genetic and clinical predictors of suicide. |
Method Keywords | genotyping |
Result | We found two upstream and two intronic SNPs associated with suicide. No direct effect of these variants was observed on IABs. However, a slight association with reward dependence scores was found. Controlling for suicide risk factors, two SNPs (rs4448731 and rs4641527) significantly predicted suicide, along with cluster B personality disorders and family history of suicide. |
Conclusions | The TPH2 gene and its 5' upstream region variants may be involved in the predisposition to suicide in MDD; however, our findings do not support the role of IABs as mediators. |
Relationships reported by
Lopez de Lara, 2007
Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
Suicide (suicide attempt)
|
symptoms |
TPH2 (TPH2) |
gene |
|
We found two upstream and two intronic SNPs of this gene associated with suicide. |
Positive
|