Study Report
Reference
| Citation | Pace, 2006 PubMed |
| Full Info | Pace, T.W., Mletzko, T.C., Alagbe, O., Musselman, D.L., Nemeroff, C.B., Miller, A.H. and Heim, C.M. (2006) Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am J Psychiatry, 163, 1630-1633.
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Study
| Hypothesis or Background |
The authors sought to determine innate immune system activation following psychosocial stress in patients with major depression and increased early life stress.
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| Sample Information | medically healthy male subjects with current major depression and increased early life stress (N=14) versus nondepressed male comparison subjects (N=14) |
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| Method Detail | Plasma interleukin (IL)-6, lymphocyte subsets, and DNA binding of nuclear factor (NF)-kB in peripheral blood mononuclear cells were compared in medically healthy male subjects with current major depression and increased early life stress (N=14) versus nondepressed male comparison subjects (N=14) before and after completion of the Trier Social Stress Test. |
| Method Keywords | blood analysis |
| Result | Trier Social Stress Test-induced increases in IL-6 and NF-kappaB DNA-binding were greater in major depression patients with increased early life stress and independently correlated with depression severity, but not early life stress. Natural killer (NK) cell percentages also increased following stress. However, there were no differences between groups and no correlation between NK cell percentage and stress-induced NF-kappaB DNA-binding or IL-6. |
| Conclusions | Male major depression patients with increased early life stress exhibit enhanced inflammatory responsiveness to psychosocial stress, providing preliminary indication of a link between major depression, early life stress and adverse health outcomes in diseases associated with inflammation. |
Relationships reported by
Pace, 2006
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Interleukin-6 (IL-6) |
protein |
|
Trier Social Stress Test-induced increases in IL-6 and NF-kappaB DNA-binding were greater in major depression patients with increased early life stress and independently correlated with depression severity, but not early life stress. |
Positive
|
|
MDD
|
syndrome |
Nuclear factor NF-kappa-B p105 subunit (NF-kappaB) |
protein |
|
Trier Social Stress Test-induced increases in IL-6 and NF-kappaB DNA-binding were greater in major depression patients with increased early life stress and independently correlated with depression severity, but not early life stress. |
Positive
|
|
Stress (stress)
|
environment |
Killer Cells, Natural (Natural killer (NK) cell) |
cell |
|
Natural killer (NK) cell percentages also increased following stress. |
Positive
|
