Study Report
Reference
| Citation | Liu, 2006 PubMed |
| Full Info | Liu, Z., Zhu, F., Wang, G., Xiao, Z., Wang, H., Tang, J., Wang, X., Qiu, D., Liu, W., Cao, Z. et al. (2006) Association of corticotropin-releasing hormone receptor1 gene SNP and haplotype with major depression. Neurosci Lett, 404, 358-362.
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Study
| Hypothesis or Background |
The dysregulation of the activity of the hypothalamic-pituitary-adrenocortical (HPA) axis system is one of the major neuroendocrine abnormalities in major depression (MD). Many pieces of evidence supported that corticotropin-releasing hormone (CRH) play a role in the pathophysiology of major depression.
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| Sample Information | patients diagnosed with major depression and matched controls |
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| Method Detail | In this article, whether genetic variations in the corticotropin-releasing hormone receptor1 (CRHR1) gene might be associated with increased susceptibility to major depression was studied by using a gene-based association analysis of single-nucleotide polymorphisms (SNPs). Three SNPs were identified in CRHR1 gene and genotyped in the samples of patients diagnosed with major depression and matched controls. |
| Method Keywords | genotyping |
| Result | We observed significant allele (P=0.0008) and genotype (P=0.0002) association with rs242939, and the haplotype defined by alleles G-G-T for the represent rs1876828, rs242939 and rs242941 was significantly over-represented in major depression patients compared to controls. |
| Conclusions | These results support the idea that the CRHR1 gene is likely to be involved in the genetic vulnerability for major depression. |
Relationships reported by
Liu, 2006
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
rs242939 (rs242939) |
SNP |
P-value=0.0002 |
We observed significant allele (P=0.0008) and genotype (P=0.0002) association with rs242939, and the haplotype defined by alleles G-G-T for the represent rs1876828, rs242939 and rs242941 was significantly over-represented in major depression patients compared to controls. |
Positive
|
|
MDD
|
syndrome |
CRHR1 (CRHR1) |
gene |
P-value<0.001 |
We observed significant allele (P=0.0008) and genotype (P=0.0002) association with rs242939, and the haplotype defined by alleles G-G-T for the represent rs1876828, rs242939 and rs242941 was significantly over-represented in major depression patients compared to controls. |
Positive
|
