Study Report
Reference
| Citation | Frodl, 2004 PubMed |
| Full Info | Frodl, T., Meisenzahl, E.M., Zill, P., Baghai, T., Rujescu, D., Leinsinger, G., Bottlender, R., Schule, C., Zwanzger, P., Engel, R.R. et al. (2004) Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression. Arch Gen Psychiatry, 61, 177-183.
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Study
| Hypothesis or Background |
Substantial evidence supports a role for dysfunction of the serotonin transporter in the pathogenesis of major depression. Several studies have found reciprocal interactions between the serotonergic system and both brain-derived neurotrophic factor and glutamate, which are known to modulate or affect hippocampal morphologic characteristics.
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| Sample Information | 40 inpatients with major depression as well as 40 healthy controls |
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| Method Detail | MRI; genotyping |
| Method Keywords | magnetic resonance imaging (MRI); genotyping |
| Result | Patients with the L/L homozygous genotype had significantly smaller hippocampal gray matter (left hemisphere: P=.003; right hemisphere: P=.01) and white matter volumes (left hemisphere: P=.001; right hemisphere: P=.002) than controls with this genotype. No significant differences were found between patients and controls with the L/S or S/S genotype. Moreover, patients with the L/L genotype had significantly smaller hippocampal white matter volumes than those with the L/S or S/S genotype (P=.03). |
| Conclusions | Patients with the L/L homozygous genotype had significantly smaller hippocampal gray matter (left hemisphere: P=.003; right hemisphere: P=.01) and white matter volumes (left hemisphere: P=.001; right hemisphere: P=.002) than controls with this genotype. No significant differences were found between patients and controls with the L/S or S/S genotype. Moreover, patients with the L/L genotype had significantly smaller hippocampal white matter volumes than those with the L/S or S/S genotype (P=.03). |
Relationships reported by
Frodl, 2004
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
|
syndrome |
RAB13 (RAB13) |
gene |
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Genes differentially expressed in major depression |
Positive
|
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Hippocampus (hippocampus)
|
brain morphology and function |
SLC6A4 (5-HTT) |
gene |
P-value<0.01 |
Patients with the L/L homozygous genotype had significantly smaller hippocampal gray matter (left hemisphere: P=.003; right hemisphere: P=.01) and white matter volumes (left hemisphere: P=.001; right hemisphere: P=.002) than controls with this genotype. |
Positive
|
