Brain Morphology and Function Report

Name	left hippocampus
Brain Morphology	Please reference to the description for Hippocampus
No. of Studies (Positive/Negative)	10(10/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
left hippocampus	Saxena, 2001	patients and normal controls		Left hippocampal metabolism was significantly lower in subje...... Left hippocampal metabolism was significantly lower in subjects with MDD alone and in subjects with concurrent OCD+MDD than in control subjects or subjects with OCD alone. Hippocampal metabolism was negatively correlated with depression severity across all subjects. More...
left hippocampal volume	Vythilingam, 2002	patients and normal controls	18% smaller; 15% smaller	The depressed subjects with childhood abuse had an 18% small...... The depressed subjects with childhood abuse had an 18% smaller mean left hippocampal volume than the nonabused depressed subjects and a 15% smaller mean left hippocampal volume than the healthy subjects. More...
left hippocampus	Kumari, 2003	patients and normal controls		Compared with control participants, patients showed relative...... Compared with control participants, patients showed relatively decreased response in the hippocampus (all left) with positive picture-caption pairs. More...
left hippocampus	MacMaster, 2004	patients and normal controls	P-value = 0.001	An analysis of covariance revealed a significant difference ...... An analysis of covariance revealed a significant difference between MDD and control subjects (F = 8.66, df = 1, 29, P = 0.006). This was more strongly localized to the left hippocampus (P = 0.001) than the right hippocampus (P = 0.047). Our findings provide new evidence of abnormalities in the hippocampus in early onset depression. More...
left hippocampal volumes	Caetano, 2007	patients and normal controls	F=2.8, df =2/38, P-value = 0.07; effect size: eta2(p) =0.13	Unmedicated depressed patients showed a trend towards smalle...... Unmedicated depressed patients showed a trend towards smaller left hippocampal volumes compared to medicated patients and healthy subjects More...
left hippocampal gyrus	Vasic, 2008	patients and normal controls		Patients with depression showed reduced gray matter volume (...... Patients with depression showed reduced gray matter volume (GMV) was found in the left hippocampal gyrus More...
left hippocampus	Shamim, 2009	patients only		Patients with a diagnosis of depression and a right temporal...... Patients with a diagnosis of depression and a right temporal seizure focus had significantly lower left hippocampal volume. More...
left hippocampus	Gonul, 2011	patients and normal controls		Depressed patients had smaller left hippocampal volumes comp...... Depressed patients had smaller left hippocampal volumes compared to healthy controls. More...
left hippocampus	Steffens, 2011	patients and normal controls	mean difference = 0.013 SD = 0.0059, t = 2.18, df = 160, P-value <0.0305	over 2 years, the depressed group showed a greater reduction...... over 2 years, the depressed group showed a greater reduction in left hippocampal volume compared with the nondepressed group (mean difference = 0.013 +/- 0.0059, t = 2.18, df = 160, p <0.0305). More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
left hippocampus		BDNF(Val66Met BDNF)	gene	Gonul, 2011	patients and normal controls		among Val homozygotes depressed patients had significantly s...... among Val homozygotes depressed patients had significantly smaller left hippocampal volumes compared to controls. More...
left hippocampus		Glutamatergic system(glutamatergic system)	neurobiological system	Saxena, 2001	patients and normal controls		Left hippocampal metabolism was significantly lower in subje...... Left hippocampal metabolism was significantly lower in subjects with MDD alone and in subjects with concurrent OCD+MDD than in control subjects or subjects with OCD alone. Hippocampal metabolism was negatively correlated with depression severity across all subjects. More...
left hippocampal volume		Child abuse(childhood abuse)	environment	Vythilingam, 2002	patients and normal controls		The depressed subjects with childhood abuse had an 18% small...... The depressed subjects with childhood abuse had an 18% smaller mean left hippocampal volume than the nonabused depressed subjects and a 15% smaller mean left hippocampal volume than the healthy subjects. More...
left hippocampal volume		Life events(major life events)	environment	Kronmuller, 2008	patients only		A significant negative correlation between major life events...... A significant negative correlation between major life events three month before the onset of depression and the left hippocampal volume was found for male patients. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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