Brain Morphology and Function Report

Name	inferior orbitofrontal cortex
Brain Morphology	Please reference to the description for Orbitofrontal cortex
No. of Studies (Positive/Negative)	3(3/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
inferior orbitofrontal cortex (OFC)	Lee, 2008	patients and normal controls		When shown pictures of sad faces, patients with MDD relative...... When shown pictures of sad faces, patients with MDD relative controls showed decreased activations bilaterally in the inferior orbitofrontal cortex (OFC). We also found significant group differences under the angry face condition, bilaterally, in the inferior OFC. More...
inferior orbitofrontal cortex (OFC)	Mak, 2009	patients and normal controls		The depressed participants showed specific difficulty in reg...... The depressed participants showed specific difficulty in regulating negative emotion, which was associated with reduced GMV and concentration in the anterior cingulate cortex (ACC) and the inferior orbitofrontal cortex (OFC). Abnormal structures in the ACC and OFC and the dysregulation of negative emotion may relate to the pathology of major depressive disorder. More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
inferior orbitofrontal cortex (OFC)		Emotion(dysregulation of negative emotion)	cognition and behavior	Mak, 2009	patients and normal controls		The depressed participants showed specific difficulty in reg...... The depressed participants showed specific difficulty in regulating negative emotion, which was associated with reduced GMV and concentration in the anterior cingulate cortex (ACC) and the inferior orbitofrontal cortex (OFC). Abnormal structures in the ACC and OFC and the dysregulation of negative emotion may relate to the pathology of major depressive disorder. More...
bilateral inferior orbitofrontal areas		Depressed mood(depression)	symptoms	Lee, 2007	patients and normal controls		Within the MDD group, the severity of depression correlated ...... Within the MDD group, the severity of depression correlated with the activity of the bilateral inferior orbitofrontal areas to negative pictures. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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