Symptoms Report

Name	Somatic symptoms
Description	Somatic symptoms are common in patients with MDD, including fatigue and lack of energy and painful physical symptoms such as headaches and back pain. According to an analysis of data from the World Health Organization, 69% of patients in primary care settings meeting the DSM-IV/ICD-10 criteria for depression presented somatic symptoms as their primary reason for seeking medical care. Somatic symptoms in depressed patients, in particular painful physical symptoms, are associated with more severe depression of longer duration and greater functional impairment, poorer clinical outcome and higher health-care costs. Furthermore, the overlap of somatic symptoms associated with depression with other medical illnesses can impact accurate diagnosis and lead to the under-recognition of depression and misdiagnosis (Vaccarino et al, 2008; PMID: 18280580).
No. of Studies (Positive/Negative)	5 (5/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
chronic painful physical condition	Ohayon, 2004	patients only		Compared with MDD subjects without chronic pain, MDD subject...... Compared with MDD subjects without chronic pain, MDD subjects with a CPPC(chronic painful physical condition) had a longer duration of depressive symptoms (7 months longer) More...
somatic symptoms	Vaccarino, 2008	patients only		These results demonstrate a high prevalence and association ...... These results demonstrate a high prevalence and association of somatic symptoms in patients with MDD More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
general somatic symptoms		Slow wave potential(temporal slow waves)	neurobiological system	Motomura, 2002	patients and normal controls	P-value <0.01	each score of HAMD in patients with temporal slow waves show...... each score of HAMD in patients with temporal slow waves showed a significantly higher score for general somatic symptoms (P<0.01) More...
somatic-vegetative symptoms		Anterior cingulate cortex(anterior cingulate cortex)	brain morphology and function	Heinzel, 2009	patients only		somatic-vegetative symptoms correlated with signal changes i...... somatic-vegetative symptoms correlated with signal changes in the pre-genual anterior cingulate cortex. More...
chronic painful physical condition		Attention(severe difficulty concentrating)	cognition and behavior	Ohayon, 2004	patients only		Compared with MDD subjects without chronic pain, MDD subject...... Compared with MDD subjects without chronic pain, MDD subjects with a CPPC(chronic painful physical condition) had a longer duration of depressive symptoms (7 months longer) and were more likely to report severe difficulty concentrating (OR = 1.7), and severe feelings of sadness or depressed mood (OR = 1.8). More...
chronic painful physical condition		Depressed mood(depressed mood)	symptoms	Ohayon, 2004	patients only		Compared with MDD subjects without chronic pain, MDD subject...... Compared with MDD subjects without chronic pain, MDD subjects with a CPPC(chronic painful physical condition) had a longer duration of depressive symptoms (7 months longer) and were more likely to report severe feelings of sadness or depressed mood (OR = 1.8). More...
chronic painful physical condition		Fatigue(fatigue)	symptoms	Ohayon, 2004	patients only		Compared with MDD subjects without chronic pain, MDD subject...... Compared with MDD subjects without chronic pain, MDD subjects with a CPPC(chronic painful physical condition) had a longer duration of depressive symptoms (7 months longer) and were more likely to report severe fatigue (OR = 5.4), More...
chronic painful physical condition		Sleep disturbances(insomnia)	symptoms	Ohayon, 2004	patients only		Compared with MDD subjects without chronic pain, MDD subject...... Compared with MDD subjects without chronic pain, MDD subjects with a CPPC(chronic painful physical condition) had a longer duration of depressive symptoms (7 months longer) and were more likely to report insomnia nearly every night (OR = 3.3), More...
chronic painful physical condition		Low energy(psychomotor retardation)	symptoms	Ohayon, 2004	patients only		Compared with MDD subjects without chronic pain, MDD subject...... Compared with MDD subjects without chronic pain, MDD subjects with a CPPC(chronic painful physical condition) had a longer duration of depressive symptoms (7 months longer) and were more likely to report severe psychomotor retardation (OR = 3.3), More...
chronic painful physical condition		Increased appetite(weight gain)	symptoms	Ohayon, 2004	patients only		Compared with MDD subjects without chronic pain, MDD subject...... Compared with MDD subjects without chronic pain, MDD subjects with a CPPC(chronic painful physical condition) had a longer duration of depressive symptoms (7 months longer) and were more likely to report weight gain (OR = 2.3), More...
pain		Sleep disturbances(sleep disturbances)	symptoms	Chung, 2010	patients only		Cross-sectional analyses found that insomnia symptoms and qu...... Cross-sectional analyses found that insomnia symptoms and quantitative sleep parameters were related to pain symptoms.This study supports specific role of subjective sleep disturbances and actigraphic measures in predicting pain symptoms in major depressive disorder. More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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