Gene Report

Basic Information

Approved Symbol	RAP1GAP
Approved Name	RAP1 GTPase activating protein
Previous Symbol	RAP1GA1
Previous Name	"RAP1, GTPase activating protein 1"
Symbol Alias	KIAA0474, RAP1GAP1, RAP1GAPII
Location	1p36.1-p35
Position	chr1:21996010-21996010 (-)
External Links	Entrez Gene: 5909 Ensembl: ENSG00000076864 UCSC: uc001bew.3 HGNC ID: 9858
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RAP1GAP and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
RAP1, GTPase activating protein 1	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between RAP1GAP and other components at different levels (count: 0)

Positive relationship network of RAP1GAP in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RAP1GAP and MDD (count: 0)

Negative relationships between RAP1GAP and other components at different levels (count: 0)

RAP1GAP related SNPs in MK4MDD (count: 0)

RAP1GAP related proteins in MK4MDD (count: 0)

RAP1GAP related GO terms (count: 23)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005515	protein binding	molecular function	IPI[18309292\|20877310]
GO:0003924	GTPase activity	molecular function	NAS[10476970]
GO:0005096	GTPase activator activity	molecular function	IDA[15141215]
GO:1904425	negative regulation of GTP binding	biological process	IEA
GO:0050766	positive regulation of phagocytosis	biological process	IEA
GO:0016020	membrane	cellular component	IDA[10476970]
GO:0043025	neuronal cell body	cellular component	IEA
GO:0030425	dendrite	cellular component	IEA
GO:0045665	negative regulation of neuron differentiation	biological process	IEA
GO:1990792	cellular response to glial cell derived neurotrophic factor	biological process	IEA
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	IEA
GO:0005829	cytosol	cellular component	IDA[10476970]; TAS
GO:0000139	Golgi membrane	cellular component	IEA
GO:0007165	signal transduction	biological process	NAS[10476970]
GO:0005769	early endosome	cellular component	IEA
GO:0017016	Ras GTPase binding	molecular function	IPI[18309292]
GO:1903697	negative regulation of microvillus assembly	biological process	IMP[22797597]
GO:0043547	positive regulation of GTPase activity	biological process	IDA[15141215]
GO:1904442	negative regulation of thyroid gland epithelial cell proliferation	biological process	IEA
GO:0043087	regulation of GTPase activity	biological process	IDA[18309292]
GO:0022409	positive regulation of cell-cell adhesion	biological process	IEA
GO:0042803	protein homodimerization activity	molecular function	IPI[18309292]
GO:0030424	axon	cellular component	IEA

RAP1GAP related KEGG pathways (count: 0)

RAP1GAP related BioCarta pathways (count: 0)

RAP1GAP related Reactome pathways (count: 0)

RAP1GAP related interactors from protein-protein interaction data in HPRD (count: 10)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
RAP1GAP	RALGDS	No	in vitro	12464615
RAP1GAP	ZBTB12	No	in vitro;yeast 2-hybrid	8939933
RAP1GAP	GNAZ	No	in vitro;yeast 2-hybrid	10593970
RAP1GAP	BRAF	No	in vitro;in vivo	10854065 , 11278445
RAP1GAP	MLLT4	No	in vitro;yeast 2-hybrid	12590145
RAP1GAP	PFN2	No	yeast 2-hybrid	16169070
RAP1GAP	CDK1	No	in vitro	1406653
RAP1GAP	PRKACA	No	in vitro	1406653
RAP1GAP	MEX3B	No	yeast 2-hybrid	16169070
RAP1GAP	RAP1GAP	Yes	in vitro	15141215

Gene Report

Gene mapped GO terms