Gene Report

Basic Information

Approved Symbol	NR1D1
Approved Name	nuclear receptor subfamily 1, group D, member 1
Previous Symbol	THRAL
Symbol Alias	ear-1, hRev, Rev-ErbAalpha, THRA1
Location	17q11.2
Position	chr17:38249037-38256973 (-)
External Links	Entrez Gene: 9572 Ensembl: ENSG00000126368 UCSC: uc002htz.2 HGNC ID: 7962
No. of Studies (Positive/Negative)	1(0/1)
Type	Literature-origin

Positive relationships between NR1D1 and MDD (count: 0)

Positive relationships between NR1D1 and other components at different levels (count: 0)

Positive relationship network of NR1D1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between NR1D1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NR1D1	Kishi T, 2008	Patients and nomal controls		No significant association was found with major depressive d...... No significant association was found with major depressive disorder More...

Negative relationships between NR1D1 and other components at different levels (count: 0)

NR1D1 related SNPs in MK4MDD (count: 0)

NR1D1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Nuclear receptor subfamily 1 group D member 1	P20393	0(0/0)	Gene mapped

NR1D1 related GO terms (count: 18)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS
GO:0000790	nuclear chromatin	cellular component	IDA[18511497]
GO:0005634	nucleus	cellular component	TAS[8622974]
GO:0007623	circadian rhythm	biological process	IEA
GO:0005654	nucleoplasm	cellular component	TAS
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	molecular function	TAS[8622974]
GO:0030522	intracellular receptor mediated signaling pathway	biological process	TAS[8622974]
GO:0010467	gene expression	biological process	TAS
GO:0071222	cellular response to lipopolysaccharide	biological process	IMP[18511497]
GO:0003714	transcription corepressor activity	molecular function	TAS[8622974]
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IMP[18511497]
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA[18511497]
GO:0043565	sequence-specific DNA binding	molecular function	IEA
GO:0010871	negative regulation of receptor biosynthetic process	biological process	IMP[18511497]
GO:0008270	zinc ion binding	molecular function	IEA
GO:0003707	steroid hormone receptor activity	molecular function	IEA
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	biological process	IMP[18511497]
GO:2000189	positive regulation of cholesterol homeostasis	biological process	IDA[18511497]

NR1D1 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04710	circadian rhythm_mammal	Circadian rhythm - mammal

NR1D1 related BioCarta pathways (count: 0)

NR1D1 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_15525	nuclear receptor_transcription_pathway	A classic example of bifunctional transcription factors is t...... A classic example of bifunctional transcription factors is the family of Nuclear Receptor ). For example, binding of thyroid hormone (TH) to the human TH Receptor (THRA or THRB) was found to result in the recruitment of a specific complex of Thyroid Receptor Associated Proteins - the TRAP coactivator complex - of which the TRAP220 subunit was later identified to be the Mediator 1 (MED1) homologue. Similarly, binding of Vitamin D to the human Vitamin D3 Receptor was found to result in the recruitment of a specific complex of D Receptor Interacting Proteins - the DRIP coactivator complex, of which the DRIP205 subunit was later identified to be human MED1. More...
REACT_71	gene expression	Gene Expression covers the process of transcription of mRNA ...... Gene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The expression of non-protein-coding genes is not included in this section yet. However, the transcription of RNAs other than mRNA is described in the section on transcription; in the sections 'RNA Polymerase I Transcription', and 'RNA Polymerase III Transcription'. More...

NR1D1 related interactors from protein-protein interaction data in HPRD (count: 5)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
NR1D1	NR1D2	No	yeast 2-hybrid	15604093
NR1D1	NR1D1	Yes	in vitro	11669620 , 9660968
NR1D1	NCOR2	No	in vitro;yeast 2-hybrid	16219912 , 15604093
NR1D1	NR2E3	No	in vitro;yeast 2-hybrid	15190009
NR1D1	NCOR1	No	in vitro;in vivo;yeast 2-hybrid	8948627 , 9482666 , 15604093

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways