Protein Report

Basic Information

Protein Name	Interleukin-1 beta
UniPortKB	P01584
No. of Studies (Positive/Negative)	6 (4/2)
Type	Literature-origin

Positive relationship between Interleukin-1 beta and MDD (count: 3)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
IL-1beta	Marques-Deak, 2007	patients and normal controls		Evaluations of serum IL-1beta, IL-6, IFN-gamma and cortisol ...... Evaluations of serum IL-1beta, IL-6, IFN-gamma and cortisol were performed on both groups. Patients were evaluated prior and after antidepressant treatment. After remission of the symptoms, patients with MDD evolved with enhancement of cytokine levels, but no differences were observed in cortisol levels. More...
IL1-¦Â	Leo, 2006	patients and normal controls		Compared with control subjects, MDD patients had higher base...... Compared with control subjects, MDD patients had higher baseline levels of IL1-¦Â More...
IL1-¦Â	Piletz, 2010	patients and normal controls	P-value=0.03	Compared to controls, patients with MDD had significantly hi...... Compared to controls, patients with MDD had significantly higher baseline levels of interleukin-1beta (IL1beta, P=0.03) in the blood. More...

Positive relationships between Interleukin-1 beta and other components at different levels (count: 4)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
IL-1beta		Indoleamine 2,3-dioxygenase 1(indolamine-2,3-dioxygenase)	protein	Zunszain PA, 2012	cell model	Analysis of the enzymes that regulate the kynurenine pathway...... Analysis of the enzymes that regulate the kynurenine pathway showed that IL-1beta induced an upregulation of transcripts for indolamine-2,3-dioxygenase (IDO), kynurenine 3-monooxygenase (KMO), and kynureninase (42-, 12- and 30-fold increase, respectively, under differentiating conditions) More...
IL-1beta		Kynurenine 3-monooxygenase(kynurenine 3-monooxygenase)	protein	Zunszain PA, 2012	cell model	Analysis of the enzymes that regulate the kynurenine pathway...... Analysis of the enzymes that regulate the kynurenine pathway showed that IL-1beta induced an upregulation of transcripts for indolamine-2,3-dioxygenase (IDO), kynurenine 3-monooxygenase (KMO), and kynureninase (42-, 12- and 30-fold increase, respectively, under differentiating conditions) More...
IL-1beta		Kynureninase(kynureninase)	protein	Zunszain PA, 2012	cell model	Analysis of the enzymes that regulate the kynurenine pathway...... Analysis of the enzymes that regulate the kynurenine pathway showed that IL-1beta induced an upregulation of transcripts for indolamine-2,3-dioxygenase (IDO), kynurenine 3-monooxygenase (KMO), and kynureninase (42-, 12- and 30-fold increase, respectively, under differentiating conditions) More...
IL-1beta		Kynurenine(kynurenine)	molecule	Zunszain PA, 2012	cell model	treatment with IL-1beta resulted in an increase in kynurenin...... treatment with IL-1beta resulted in an increase in kynurenine, the catabolic product of IDO-induced tryptophan metabolism More...

Positive relationship network of Interleukin-1 beta in MK4MDD

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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between Interleukin-1 beta and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
interleukin-1beta	Einvik G, 2012	patients and normal controls		Group comparisons revealed no significant difference in the ...... Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1beta, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1beta] between persons with (n=34) and without MDD (n=68) More...
IL-1beta	Hughes MM, 2012	patients and normal controls		Whilst no changes in TNF-alpha or IL-1beta were observed, pl...... Whilst no changes in TNF-alpha or IL-1beta were observed, plasma concentrations of IL-6, IFN-gamma and CRP were increased in the depressed cohort. More...

Negative relationships between Interleukin-1 beta and other components at different levels (count: 0)

Related Gene Info

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
IL1B	interleukin 1, beta	Literature-origin; SNP mapped; Protein mapped	3 (2/1)