MK4MDD

Protein Report

Basic Information
Protein Name Interleukin-1 beta
UniPortKB P01584
No. of Studies (Positive/Negative) 6 (4/2) Help
Type Literature-origin
Positive relationship between Interleukin-1 beta and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
IL-1beta Marques-Deak, 2007 patients and normal controls Evaluations of serum IL-1beta, IL-6, IFN-gamma and cortisol ...... Evaluations of serum IL-1beta, IL-6, IFN-gamma and cortisol were performed on both groups. Patients were evaluated prior and after antidepressant treatment. After remission of the symptoms, patients with MDD evolved with enhancement of cytokine levels, but no differences were observed in cortisol levels. More...
IL1-¦Â Leo, 2006 patients and normal controls Compared with control subjects, MDD patients had higher base...... Compared with control subjects, MDD patients had higher baseline levels of IL1-¦Â More...
IL1-¦Â Piletz, 2010 patients and normal controls P-value=0.03 Compared to controls, patients with MDD had significantly hi...... Compared to controls, patients with MDD had significantly higher baseline levels of interleukin-1beta (IL1beta, P=0.03) in the blood. More...

Positive relationships between Interleukin-1 beta and other components at different levels (count: 4) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Positive relationship network of Interleukin-1 beta in MK4MDD
Network loading ...

network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Interleukin-1 beta and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description
interleukin-1beta Einvik G, 2012 patients and normal controls Group comparisons revealed no significant difference in the ...... Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1beta, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1beta] between persons with (n=34) and without MDD (n=68) More...
IL-1beta Hughes MM, 2012 patients and normal controls Whilst no changes in TNF-alpha or IL-1beta were observed, pl...... Whilst no changes in TNF-alpha or IL-1beta were observed, plasma concentrations of IL-6, IFN-gamma and CRP were increased in the depressed cohort. More...

Negative relationships between Interleukin-1 beta and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
IL1B interleukin 1, beta Literature-origin; Protein mapped 4 (3/1)