Protein Report

Protein Name	Interferon gamma
UniPortKB	P01579
No. of Studies (Positive/Negative)	10 (8/2)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
IFN-gamma	Myint, 2005	patients and normal controls		The proportion of patients who showed immunoreactivity to IF...... The proportion of patients who showed immunoreactivity to IFN-gamma and IL-4 in the plasma, and the plasma IFN-gamma/IL-4 ratio, were significantly higher in depressed patients than in controls. The IFN-gamma/TGF-beta1 ratio was also higher in depressed patients More...
IFN-gamma	Marques-Deak, 2007	patients and normal controls		Evaluations of serum IL-1beta, IL-6, IFN-gamma and cortisol ...... Evaluations of serum IL-1beta, IL-6, IFN-gamma and cortisol were performed on both groups. Patients were evaluated prior and after antidepressant treatment. After remission of the symptoms, patients with MDD evolved with enhancement of cytokine levels, but no differences were observed in cortisol levels. More...
IFN-gamma	Pavon, 2006	patients and normal controls		Higher levels of IL-4 and IL-13 (Th2) and significantly lowe...... Higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-gamma (Th1) cytokines were also observed in the MDD group More...
interferon-gamma (IFN-gamma)	Kim, 2007	patients and normal controls		At admission IFN-gamma, IL-2, and IL-4 were significantly lo...... At admission IFN-gamma, IL-2, and IL-4 were significantly lower in MDD patients. More...
interferon-gamma (IFN-gamma)	Kim, 2008	patients and normal controls		Both MDD groups, with or without attempted suicide, had sign...... Both MDD groups, with or without attempted suicide, had significantly lower IFN-gamma and IL-4 and higher TGF-beta1 production. HDRS(Hamilton's depression rating scale) scores had significant positive correlations with IFN-gamma More...
interferon-gamma (IFN-gamma)	Gabbay, 2009	patients and normal controls	P-value<0.003	Adolescents with MDD had significantly elevated plasma IFN-g...... Adolescents with MDD had significantly elevated plasma IFN-gamma levels (3.38+/-11.8 pg/ml versus 0.37+/-0.64 pg/ml; p<0.003), and IFN-gamma/IL-4 ratio (16.6+/-56.5 versus 1.76+/-2.28; p=0.007). More...
interferon-gamma (IFN-gamma)	Gabbay, 2009	patients and normal controls	P-value<0.05	IFN-gamma was increased in both suicidal and nonsuicidal ado...... IFN-gamma was increased in both suicidal and nonsuicidal adolescents with MDD compared to controls (2.14 +/- 6.22 and 4.20 +/- 14.48 versus 0.37 +/- 0.64; p < 0.02, p = 0.005). More...
IFN-gamma	Hughes MM, 2012	patients and normal controls		Whilst no changes in TNF-alpha or IL-1beta were observed, pl...... Whilst no changes in TNF-alpha or IL-1beta were observed, plasma concentrations of IL-6, IFN-gamma and CRP were increased in the depressed cohort. More...

---

network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
IFN gamma	Farid Hosseini R, 2007	patients and nomal controls		We found no significant differences in plasma concentration ...... We found no significant differences in plasma concentration of IL-4, IL-10, TNF-alpha, IFN-gamma, and immunoglobulins as well as total number of NK cells, B cells, and T cells between major depressed patients and healthy control subjects. More...
interferon-gamma	Einvik G, 2012	patients and normal controls		Group comparisons revealed no significant difference in the ...... Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1beta, -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte-monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1beta] between persons with (n=34) and without MDD (n=68) More...

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
IFNG	interferon, gamma	Literature-origin; Protein mapped	1 (1/0)